Course Overview - Sept. 29 (Biochem 230 information and tips on critical reading)

Paper#1:

Discussion#1 - Oct. 1 HIV and AIDS

Paper 1:Barber, D.L. et al, (2006). "Restoring function in exhausted CD8 T cells during chronic viral infection." Nature. 439(7077):682-7.

Paper 2: Steigbigel, R.T. et al, (2008). "Raltegravir with Optimized Background Therapy for Resistant HIV-1 Infection ." N. Engl. J. Med. July 24; 359(4):339-54.

Background:

Discussion#2 - Oct 8 Statins

Paper 1: Garcia-Calvo, M. et al. (2005). "The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)." Proc. Natl. Acad. Sci. U S A. Jun 7;102(23):8132-7

Paper 2: The SEARCH Collaborative Group. (2008). "SLCO1B1 Variants and Statin-Induced Myopathy — A Genomewide Study." N. Engl. J. Med. Aug. 21;359(8):789-99.

Background:

Discussion#3 - Oct. 15 The Obesity Epidemic

Paper 1: Gerken, T., et al. (2007) "The Obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase." Science. Nov.30;318(5855):1469-72.

Paper 2: Frayling, T.M., et al. (2007) "A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity." Science. May 11;316(5826):889-94.

Background:

Discussion#4 - Oct. 22 Diabetes (TYPE 1)

Paper 1: Voltarelli, J., et al. (2007) "Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus." JAMA. Apr. 11;297(14):1568-76.

Paper 2: Zhou, Q., et al., (2008) "In vivo reprogramming of adult pancreatic exocrine cells to beta-cells." Nature . Oct. 2;455(7213):627-32.

Background:

Brownlee, M., (2001) "Biochemistry and molecular cell biology of diabetic complications." Nature. Dec 13;414(6865):813-20.

Bollyky, J., et al. (2008) "Type 1 diabetes mellitus: primary, secondary, and tertiary prevention."Mt. Sinai J. Med. Aug;75(4):385-97.

Discussion#5 - Oct. 29 Pandemic Influenza

Paper 1 : Morens, D.L., et al, (2008). "Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness." J. Infect. Dis. Oct 1;198(7):962-70.

Paper 2: Stevens, J. et al, ( 2008). "Recent avian H5N1 viruses exhibit increased propensity for acquiring human receptor specificity." J. Mol. Bio. Sep 19;381(5):1382-94.

Background:

Taubenberger, J.K., Morens, D.M., (2006). "1918 Influenza: the mother of all pandemics." Emerg. Infect. Dis. Jan;12(1):15-22.

Writing Committee of the Second World Health Organization Consultation on Clinical Aspects of Human Infection with Avian Influenza A (H5N1) Virus, Abdel-Ghafar AN, Chotpitayasunondh T, Gao Z, Hayden FG, Nguyen DH, de Jong MD, Naghdaliyev A, Peiris JS, Shindo N, Soeroso S, Uyeki TM., (2008). "Update on avian influenza A (H5N1) virus infection in humans." N. Engl. J. Med. Jan 17;358(3):261-73.

Taubenberger, J.K., Morens, D.M., ( 2008). "The pathology of influenza virus infections." Annu. Rev. Pathol. 3:499-522.

Paper 2:van Deutekom, J.C., et al, (2007). " Local Dystrophin Restoration with Antisense Oligonucleotide PRO051." N. Engl. J. Med. Dec. 27; 357(26): 2677-86.

Background:

McNally E.M., Pytel, P., (2007). "Muscle Diseases: The Muscular Dystrophies." Annu. Rev. Pathol. 2:87-109.

Bretag, H.A., (2007). "Stem cell treatment in dystrophic dogs." Nature. Dec. 20;450(7173):E23;discussion:E23-5.

Paper 1: Pardal, R., Ortega-Saenz, P., et al. (2007). " Glia-like stem cells sustain physiologic neurogenesis in the adult mammalian carotid body." Cell. Oct. 19;131(2):364-77.

Paper 2: Minguez-Castellanos, A., Escamilla-Sevilla, F., et al. ( 2007). "Carotid body autotransplantation in Parkinson disease: a clinical and positron emission tomography study." J. Neurol. Neurosurg. Psychiatry. Aug;78(8):825-31.

Background:

Background:

Forman, M.S., Trojanowski, J.Q., et al. (2004). " Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthoughs." Nat. Med. Oct;10(10):1055-63.

Prusiner, S., ( 1998). "Prions." Proc. Natl. Acad. Sci. Nov.10;95(23):13363-83.

Nov. 27 (NO CLASS - Thanksgiving Holiday)

Nov. 28 (NO CLASS - Thanksgiving Holiday)

Discussion#9 - Dec. 1 Discussion led by Josh Troke

Miller, E.J., Li, J., Leng, L., McDonald, C., Atsumi, T., Bucala, R.,and Young, L.H., (2008). " Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart." Nature. Jan. 31; 451(7178): 578-82.

Discussion#10 - Dec. 3 @ 9AM Discussion led by David Craig

Kain, R., Exner, M., Brandes, R., Ziebermayr, R., Cunningham, D., Alderson, C.A., Davidovits, A., Raab, I., Jahn, R., Ashour, O., Spitzauer, S., Sunder-Plassmann, G., Fukuda, M., Klemm, P., Rees, A.J., and Kerjasckhki, D., (2008). "Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis." Nature Medicine. Oct.;14(10):1088-96.

Discussion #11-Dec. 3 @10AM Discussion led by Joaquín Cámara-Quintana

Sanai, N., Tramontin, A.D., Quinones-Hinojosa, A., Barbaro, N.M., Gupa, N., Kunwar, S., Lawton, M.T., McDermott, M.W., Parsa, A.T., Manuel-Garcia Verdugo, J., Berger, M.S., Alvarez-Buylla, A. (2004). "Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration." Nature. Feb.19;427(6976):740-4.