David S. Hogness

    Email: hogness@cmgm.stanford.edu

Web: No lab page.

We wish to understand the mechanisms by which genes control development. We are studying two sorts of genetic regulatory hierarchies controlling development in Drosophila melanogaster. One of these specifies the segmentation pattern of the body plan along its anterior-posterior axis. Within this hierarchy we are mostly concerned with the "homeotic" genes which act as general transducers of positional information to specify the segmental identities-i.e., the characteristics that distinguish one metamere from another. The second kind of hierarchy serves to coordinate temporally the developmental pathways of different tissues at various stages of development. The coordination signal for these hierarchies consists of pulses of the steroid hormone ecdysone. Within this hierarchy, we are mostly concerned with the gene encoding the receptor protein for ecdysone and the "early" genes which are induced by the ecdysone-receptor complex to yield regulatory proteins that govern the tissue-specific responses to the ecdysone pulse.

Current work is focused on the most dramatic example of these responses where the pulse of ecdysone at the end of larval life induces metamorphosis to the adult fly, with imaginal tissues forming adult structures like eyes, wings, and legs, while strictly larval tissues are induced to follow a downward path toward histolysis.

Gavis E.R. and Hogness, D.S. (1991) Phosphorylation, expression and function of the Ultrabithorax protein family in Drosophila melanogaster. Development 112, 1077-93. (Medline)

Lopez A.J. and Hogness, D.S. (1991) Immunochemical dissection of the Ultrabithorax homeoprotein family in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA, 88, 9924-9928. (Medline)

Irvine, K.D., Botas, J., Jha, S., Mann, R.S. and Hogness, D.S. (1993) Negative autoregulation by Ultrabithorax controls the level and pattern of its expression. Development, 117, 387-99. (Medline)

Robinow, S., Talbot, W.S., Hogness, D.S. and Truman, J.W. (1993) Programmed cell death in the Drosophila CNS is ecdysone-regulated and coupled with a specific ecdysone receptor isoform. Development, 119, 1251-1259. (Medline)

Talbot, W.S., Swyryd, E.A. and Hogness, D.S. (1993) Drosophila tissues with different metamorphic responses to ecdysone express different ecdysone receptor isoforms. Cell, 73, 1323-37. (Medline)

Truman, J.W., Talbot, W.S., Fahrbach, S.E. and Hogness, D.S. (1994) Ecdysone receptor expression in the CNS correlates with stage-specific responses to ecdysteroids during Drosophila and Manduca development. Development, 120, 219-234. (Medline)