Publications:

 

P.B. Harbury, T. Zhang, P.S. Kim and T. Alber (1993). A switch Between Two-, Three- and Four-stranded Coiled Coils Revealed by Mutants of the GCN4 Leucine Zipper. Science 262:1401-1407.

P.B. Harbury, P.S. Kim and T. Alber (1994). Crystal Structure of an Isoleucine Zipper Trimer. Nature 371: 80-83.

P.B. Harbury, B. Tidor and P.S. Kim (1995). Repacking Protein Cores with Backbone Freedom: Structure Prediction for Coiled-Coils. Proc. Natl. Acad. Sci. 92: 8408-8412.

P.B. Harbury, J.J. Plecs, B. Tidor, T. Alber and P.S. Kim (1998). High Resolution Protein Design with Backbone Freedom. Science 282(5393):1462-1467.

P.B. Harbury (1998). Springs and Zippers: Coiled Coils in SNARE-mediated Membrane Fusion. Structure 6(12):1487-1491.

J. J. Havranek, P.B. Harbury (1999). Tanford-Kirkwood Electrostatics for Protein Modelling. Proc. Natl. Acad. Sci. 96:11145-11150.

C. Khosla and P.B. Harbury (2001). Modular enzymes. Nature 409(6817):247-252.

J.A. Silverman, R. Balakrishnan, and P. B. Harbury (2001). Reverse engineering the (b/a)8 barrel fold. PNAS 98(6):3092-3097.

Silverman, J.A. and P.B. Harbury (2002). MPAX footprinting: rapid mapping of protein structure, interactions, and ligand binding. J. of Biol. Chemistry 277(34):30968-30975. Patent application also submitted.

J.J. Havranek and P. B. Harbury (2002). Automated design of specificity in molecular recognition. Nature Structure Biology 10(1): 45-52.

J.A. Silverman and P. B. Harbury (2002). The equilibrium unfolding pathway of a (b/a)8-barrel. Journal of Molecular Biology 324: 1031-1040.

D.R. Halpin and P.B. Harbury (2004). DNA Display I. Sequence-Encoded Routing of DNA Populations. PLoS Biol. 2(7): 1015-1021.

D.R. Halpin and P.B. Harbury (2004). DNA Display II. Genetic Manipulation of Combinatorial Chemistry Libraries for Small-Molecule Evolution. PLoS Biol. 2(7): 1022-1030.

D.R. Halpin and P.B. Harbury (2004). DNA Display III. Solid Phase Organic Synthesis on Unprotected DNA. PLoS Biol. 2(7): 1031-1038.

J. J. Plecs, P.B. Harbury, P. S. Kim and T. Alber (2004). Structural Test of the Parameterized-backbone Method for Protein Design. JMB 342(1): 298-297.

A. S. Burguete, P.B. Harbury and S.R. Pfeffer (2004) In vitro Selection and Prediction of TIP47 Protein-Interaction Interfaces. Nat. Methods 1(1):55-60.

 

 

Some recent articles about the lab:

"Chemistry Highlights 2004" (Chemistry and Engineering News) http://pubs.acs.org/isubscribe/journals/cen/82/i51/html/8251chemistry.html

"DNA-Programmed Organic Synthesis" (Chemical and Engineering News) http://pubs.acs.org/isubscribe/journals/cen/83/i05/html/8305sci2.html

"Harnessing DNA-Based Technology for Drug Discovery" (PLoS Biology) http://www.plosbiology.org/plosonline/?request=get-document&doi=10.1371%2Fjournal.pbio.0020223

"Translating DNA into Synthetic Molecules" (PLoS Biology) http://www.plosbiology.org/plosonline/?request=get-document&doi=10.1371%2Fjournal.pbio.0020222

"A Genetic Code for Organic Chemistry" (Chemical and Engineering News) http://pubs.acs.org/isubscribe/journals/cen/82/i28/html/8228sci2.html

 

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Last Updated 5/6/05