Biochemistry 118

Sophomore Seminar
A Human Genome Stained by Fluourescent in Situ Hybridization

Genomics & Medicine

Doug Brutlag

 

In this seminar we will discuss the kind of knowledge we hope to gain from sequencing human and bacterial genomes and the implications of such knowledge for medicine and biomedical research. We will discuss novel diagnoses and treatment of diseases, including stem cells, gene therapy and rational drug design. We will also discuss the ethical implications of genetic information.

The course will be of interest to students who plan to major in biology or human biology, especially premedical students and biology majors who use molecular biology methods. It will also be useful to those interested in health care policy, intellectual-property rights and ethical issues.

Homework will include using genome and disease databases to determine the function of genes involved in disease. There are no prerequisites for this course.

Recommended Text book. This textbook is not required for the course but the following book provides an excellent introduction to the material to be covered and also basic genetics and genomics used in both medicine and research.

A Primer of Genome Science

 

 

 

 

 

 

 

 

A Primer of Genome Science

by Gibson and Muse

 

Topics for Discussion

  1. Diseases and Disease Databases
  2. Genomics
  3. Bioinformatics
  4. Stem Cell Therapies
  5. Gene Therapy
  6. Patent Policy
  7. Drug Development and the Pharmaceutical Industry
  8. Ethical Issues and Genetic Discrimination
  9. Novel Molecular Diagnostics
  10. DNA Structure
  11. Protein Structure
  12. Infectious Disease
  13. Bibliographic Search
  14. Web Resources for the course

Projects Previously Submitted for the Course

1999

2000

2001

2002

2002 Stanford Overseas Program

2003

2004

2005

2007

2008

2008 Autumn

2009 Winter

Case Presentations

2008 Autumn

2009 Winter