PUBLICATIONS

Publications by date

Regulatory genes controlling sex

Oliver, B., Kim, Y.-J., and Baker, B. S. (1993). Sex-lethal, master and slave: The hierarchy of germline sex determination in Drosophila. Development,119: 897-908.

Pultz, M. A., Carson, G., and Baker, B. S. (1994) A genetic analysis of hermaphrodite, a pleiotropic sex determination gene in Drosophila. Genetics, 136: 195-207.

Pultz, M. A., and Baker, B. S. (1995). The dual role of hermaphrodite in the Drosophila sex determination hierarchy. Development 121: 99-111.

Chase, B. A., and Baker, B. S. (1995) A genetic analysis of intersex, a gene regulating sexual differentiation in Drosophila melanogaster females. Genetics, 139:1649-1661.

Heinrichs, V., and Baker, B. S. (1995). The Drosophila SR protein RBP1 contributes to the regulation of doublesex alternative splicing by recognizing RBP1 RNA target sequences. EMBO, 14: 3987-4000.

Mattox, M., McGuffin, M. E., and Baker, B. S. (1996). A negative feedback mechanism revealed by functional analysis of the alternative isoforms of the Drosophila splicing regulator transformer-2. Genetics 143: 303-314.

Ryner, L. C., Goodwin, S. F., Castrillon, D. H., Anand, A., Villella, A., Baker, B., Hall, J. C., Taylor, B. J., and Wasserman, S. A. (1996). Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene. Cell, 87:1079-1089.

Heinrichs, V., and Baker, B. S. (1997). In vivo analysis of functional domains of the Drosophila alternative splicing factor RBP1. Proc. Natl. Acad. Sci., 94: 115-120.

Chandler, D., McGuffiin, M. E., Piskur, J., Yao, J., Baker, B. S., and Mattox, W. (1997). Evolutionary conservation of regulatory strategies for the sex determining factor transformer-2. Mol. Cell. Biol.,17: 2908-2919.

Li, H., and Baker, B. S. (1998). her, a sex differentiation gene of Drosophila, encodes a zinc finger protein with characteristics of ZFY-like proteins and is expressed independently of the sex determination hierarchy. Development, 125: 225-235.

Heinrichs, V., Ryner, L., and Baker, B. S. (1998). Regulation of fruitless sex-specific 5' splice site selection by transformer and transformer-2. Mol. Cell. Biol.,18: 450-458.

Li, H., and Baker, B. (1998). her and dsx act both dependently and independently to control various aspects of sexual differentiation in Drosophila. Development, 125: 2641-2651.

Marin, I., and Baker, B. S. (1998). The evolutionary dynamics of sex determination. Science, 281: 1990-1994.

Garrett-Engele* C. M., Siegal*, M. L., Manoli, D. S., Williams, B. C., Li. H., and Baker, B. S. (2002). intersex, a gene required for female sexual development in Drosophila, is expressed in both sexes and functions together with doublesex to regulate terminal differentiation. Development, 129: 4661-4675. (* co-first authors)

Dosage compensation

Gorman, M., Kuroda, M. and Baker, B.S. (1993). Regulation of the sex-specific binding of the maleless dosage compensation protein to the male X chromosome in Drosophila. Cell, 72: 39-49.

Gorman, M., and Baker, B. S. (1994). How flies make one equal two: dosage compensation in Drosophila. TIGS 10: 376-380.

Gorman, M., Franke, A., and Baker, B. S. (1995). Molecular characterization of the male-specific lethal-3 gene and investigations of the regulation of dosage compensation in Drosophila. Development, 121: 463-475.

Baker, B. S., Marin, I., and Gorman, M. (1994). Dosage compensation in Drosophila. Annu. Rev. Genetics, 28: 491-521.

Bashaw, G. J., and Baker, B. S. (1995). The msl-2 dosage compensation gene of Drosophila encodes a putative DNA-binding protein whose expression is sex-specifically regulated by Sex-lethal. Development, 121: 3245-3258.

Bashaw, G. J., and Baker, B. S. (1996). Dosage Compensation and chromatin structure in Drosophila. Curr. Opinions in Genet. and Dev. 496-501.

Franke, A., Dernberg, A., Bashaw, G. J., and Baker, B. S. (1996). Evidence that MSL mediated dosage compensation in Drosophila begins at blastoderm. Development 122: 2751-2760.

Marin, I., Franke, A., Bashaw, G. J., and Baker, B. S. (1996). Dosage compensation in flies: a regulatory system adapting to chromosome evolution.. Nature, 383: 160-163.

Bashaw, G. J., and Baker, B. S. (1997). The regulation of the Drosophila msl-2 gene reveals a function for Sex-lethal in translational control. Cell, 89: 789-798.

Franke, A. and Baker, B. S. (1999). The rox1 and rox2 RNAs are essential components of the Compensasome, which mediates dosage compensation in Drosophila. Molec. Cell 4: 117-122.

Franke, A. and Baker, B. S. (2000). Dosage compensation rox! Curr. Opinion in Cell Biol. 12:351-354.

Marin, I., and Baker, B. S. (2000). Origin and evolution of the regulatory gene male-specific lethal 3. Mol. Biol. Evol.17: 1240-1250.

Marin, I., Siegal, M. L. and Baker, B. S. (2000). The evolution of dosage compensation mechanisms. BioEssays, 22: 1106-1114.

Courtship behavior

Taylor, B. J., Villella, A., Ryner, L. C., Baker, B. S., and Hall, J. C. (1994). Behavioral and Neurobiological implications of sex-determining factors in Drosophila. Devel. Genetics 15: 275-296.

Ryner, L. C., Goodwin, S. F., Castrillon, D. H., Anand, A., Villella, A., Baker, B., Hall, J. C., Taylor, B. J., and Wasserman, S. A. (1996). Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene. Cell, 87:1079-1089.

Goodwin S.F., Taylor, B.J., Villella, A., Foss, M., Ryner, L. C., Baker, B. S., and Hall, J. C. (2000). Aberrant splicing and altered spatial expression patterns in fruitless mutants of Drosophila melanogaster. Genetics 154: 725-45.

Anand, A., Villella, A., Ryner, L. C., Carlo, T., Goodwin, S. F., Song, H.-J., Gailey, D. A., Hall, J. C., Baker, B. S., and Taylor, B. J. (2001). The sex determination gene fruitless , in addition to controlling male sexual behaviors, has sex-nonspecific vital functions. Genetics, 158: 1569-1595.

Baker, B. S., Taylor, B. T., and Hall, J. C. (2001). Are complex behaviors specified by dedicated regulatory genes? Reasoning from Drosophila. Cell 105: 13-24.

Song, H.-J.,. Goodwin , S. F., Reynaud, E., Carlo, T., Billeter, J.-C., Eric P. Spana, E. P., Perrimon, N., Baker, B. S., and Taylor, B. J. (2002). The fruitless gene is required for the proper formation of axonal tracts in the embryonic CNS of Drosophila. Genetics, in press.

Sexual development and differentiation

Chen, E. H., and Baker, B. S. (1997). Compartmental organization of the Drosophila genital imaginal disks. Development, 124: 205-218.

Keisman, E. L., and Baker, B. S. (2001). The Drosophila sex determination hierarchy modulates wingless and decapentaplegic signaling to sex-specifically deploy dachsund in the genital imaginal disc. Development 128: 1643-1656.

Keisman, E. L., Christiansen, A. E., and Baker, B. S. (2001). The sex determination gene doublesex (dsx) regulates the A/P organizer to direct sex-specific patterns of growth in the Drosophila genital imaginal disc. Developmental Cell, 1: 215-225.

Ahmad, S. M. and Baker, B. S. (2002). Sex-Specific deployment of FGF signaling in Drosophila recruits mesodermal cells into the male genital imaginal disc. Cell, 109, 651-661.

Christiansen, A. E., Keisman, E. L., Ahmad, S. M., and Baker, B. S. (2002). Sex comes in from the cold: the integration of sex and pattern. Trends in Genetics, 18: 510-516.

Arbeitman, M.*, Furlong, E.*, Imam, F.*, Johnson, E.*, Null, B.*, Baker, B. S., Davis, R., Krasnow, M., Scott, M., White, K.P. (2002). A genomic analysis of gene expression during the Drosophila life cycle. Science, 297: 2270-75. (*Co-first authors).

Evolution of sex

Chandler, D., McGuffiin, M. E., Piskur, J., Yao, J., Baker, B. S., and Mattox, W. (1997). Evolutionary conservation of regulatory strategies for the sex determining factor transformer-2. Mol. Cell. Biol.,17: 2908-2919.

Marin, I., and Baker, B. S. (1998). The evolutionary dynamics of sex determination. Science, 281: 1990-1994.

Marin, I., Franke, A., Bashaw, G. J., and Baker, B. S. (1996). Dosage compensation in flies: a regulatory system adapting to chromosome evolution.. Nature, 383: 160-163.

Marin, I., and Baker, B. S. (2000). Origin and evolution of the regulatory gene male-specific lethal 3. Mol. Biol. Evol.17: 1240-1250.

Marin, I., Siegal, M. L. and Baker, B. S. (2000). The evolution of dosage compensation mechanisms. BioEssays, 22: 1106-1114.

RNA splicing

Kim, Young-Yoon, and Baker, B. S. (1993). Studies on the RRM-type RNA binding protein gene family in Drosophila melanogaster using PCR with degenerate primers. Mol. Cell Bio., 13: 174-183.

Kim, Young-Yoon, and Baker, B. S. (1993). The Drosophila gene rbp9 encodes a protein that is a member of a conserved group of putative RNA binding proteins that are nervous system-specific in both flies and humans. J. Neurosci., 13(3): 1045-1056.

Heinrichs, V., and Baker, B. S. (1995). The Drosophila SR protein RBP1 contributes to the regulation of doublesex alternative splicing by recognizing RBP1 RNA target sequences. EMBO, 14: 3987-4000.

Mattox, M., McGuffin, M. E., and Baker, B. S. (1996). A negative feedback mechanism revealed by functional analysis of the alternative isoforms of the Drosophila splicing regulator transformer-2. Genetics 143: 303-314.

Ryner, L. C., Goodwin, S. F., Castrillon, D. H., Anand, A., Villella, A., Baker, B., Hall, J. C., Taylor, B. J., and Wasserman, S. A. (1996). Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene. Cell, 87:1079-1089.

Heinrichs, V., and Baker, B. S. (1997). In vivo analysis of functional domains of the Drosophila alternative splicing factor RBP1. Proc. Natl. Acad. Sci., 94: 115-120.

Chandler, D., McGuffiin, M. E., Piskur, J., Yao, J., Baker, B. S., and Mattox, W. (1997). Evolutionary conservation of regulatory strategies for the sex determining factor transformer-2. Mol. Cell. Biol.,17: 2908-2919.

Heinrichs, V., Ryner, L., and Baker, B. S. (1998). Regulation of fruitless sex-specific 5' splice site selection by transformer and transformer-2. Mol. Cell. Biol.,18: 450-458.

PUBLICATIONS

Publications by date

Regulatory genes controlling sex

Oliver, B., Kim, Y.-J., and Baker, B. S. (1993). Sex-lethal, master and slave: The hierarchy of germline sex determination in Drosophila. Development,119: 897-908.

Pultz, M. A., Carson, G., and Baker, B. S. (1994) A genetic analysis of hermaphrodite, a pleiotropic sex determination gene in Drosophila. Genetics, 136: 195-207.

Pultz, M. A., and Baker, B. S. (1995). The dual role of hermaphrodite in the Drosophila sex determination hierarchy. Development 121: 99-111.

Chase, B. A., and Baker, B. S. (1995) A genetic analysis of intersex, a gene regulating sexual differentiation in Drosophila melanogaster females. Genetics, 139:1649-1661.

Heinrichs, V., and Baker, B. S. (1995). The Drosophila SR protein RBP1 contributes to the regulation of doublesex alternative splicing by recognizing RBP1 RNA target sequences. EMBO, 14: 3987-4000.

Mattox, M., McGuffin, M. E., and Baker, B. S. (1996). A negative feedback mechanism revealed by functional analysis of the alternative isoforms of the Drosophila splicing regulator transformer-2. Genetics 143: 303-314.

Ryner, L. C., Goodwin, S. F., Castrillon, D. H., Anand, A., Villella, A., Baker, B., Hall, J. C., Taylor, B. J., and Wasserman, S. A. (1996). Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene. Cell, 87:1079-1089.

Heinrichs, V., and Baker, B. S. (1997). In vivo analysis of functional domains of the Drosophila alternative splicing factor RBP1. Proc. Natl. Acad. Sci., 94: 115-120.

Chandler, D., McGuffiin, M. E., Piskur, J., Yao, J., Baker, B. S., and Mattox, W. (1997). Evolutionary conservation of regulatory strategies for the sex determining factor transformer-2. Mol. Cell. Biol.,17: 2908-2919.

Li, H., and Baker, B. S. (1998). her, a sex differentiation gene of Drosophila, encodes a zinc finger protein with characteristics of ZFY-like proteins and is expressed independently of the sex determination hierarchy. Development, 125: 225-235.

Heinrichs, V., Ryner, L., and Baker, B. S. (1998). Regulation of fruitless sex-specific 5' splice site selection by transformer and transformer-2. Mol. Cell. Biol.,18: 450-458.

Li, H., and Baker, B. (1998). her and dsx act both dependently and independently to control various aspects of sexual differentiation in Drosophila. Development, 125: 2641-2651.

Marin, I., and Baker, B. S. (1998). The evolutionary dynamics of sex determination. Science, 281: 1990-1994.

Dosage compensation

Gorman, M., Kuroda, M. and Baker, B.S. (1993). Regulation of the sex-specific binding of the maleless dosage compensation protein to the male X chromosome in Drosophila. Cell, 72: 39-49.

Gorman, M., and Baker, B. S. (1994). How flies make one equal two: dosage compensation in Drosophila. TIGS 10: 376-380.

Gorman, M., Franke, A., and Baker, B. S. (1995). Molecular characterization of the male-specific lethal-3 gene and investigations of the regulation of dosage compensation in Drosophila. Development, 121: 463-475.

Baker, B. S., Marin, I., and Gorman, M. (1994). Dosage compensation in Drosophila. Annu. Rev. Genetics, 28: 491-521.

Bashaw, G. J., and Baker, B. S. (1995). The msl-2 dosage compensation gene of Drosophila encodes a putative DNA-binding protein whose expression is sex-specifically regulated by Sex-lethal. Development, 121: 3245-3258.

Bashaw, G. J., and Baker, B. S. (1996). Dosage Compensation and chromatin structure in Drosophila. Curr. Opinions in Genet. and Dev. 496-501.

Franke, A., Dernberg, A., Bashaw, G. J., and Baker, B. S. (1996). Evidence that MSL mediated dosage compensation in Drosophila begins at blastoderm. Development 122: 2751-2760.

Marin, I., Franke, A., Bashaw, G. J., and Baker, B. S. (1996). Dosage compensation in flies: a regulatory system adapting to chromosome evolution.. Nature, 383: 160-163.

Bashaw, G. J., and Baker, B. S. (1997). The regulation of the Drosophila msl-2 gene reveals a function for Sex-lethal in translational control. Cell, 89: 789-798.

Franke, A. and Baker, B. S. (1999). The rox1 and rox2 RNAs are essential components of the Compensasome, which mediates dosage compensation in Drosophila. Molec. Cell 4: 117-122.

Franke, A. and Baker, B. S. (2000). Dosage compensation rox! Curr. Opinion in Cell Biol. 12:351-354.

Marin, I., and Baker, B. S. (2000). Origin and evolution of the regulatory gene male-specific lethal 3. Mol. Biol. Evol.17: 1240-1250.

Marin, I., Siegal, M. L. and Baker, B. S. (2000). The evolution of dosage compensation mechanisms. BioEssays, 22: 1106-1114.

Courtship behavior

Taylor, B. J., Villella, A., Ryner, L. C., Baker, B. S., and Hall, J. C. (1994). Behavioral and Neurobiological implications of sex-determining factors in Drosophila. Devel. Genetics 15: 275-296.

Ryner, L. C., Goodwin, S. F., Castrillon, D. H., Anand, A., Villella, A., Baker, B., Hall, J. C., Taylor, B. J., and Wasserman, S. A. (1996). Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene. Cell, 87:1079-1089.

Goodwin S.F., Taylor, B.J., Villella, A., Foss, M., Ryner, L. C., Baker, B. S., and Hall, J. C. (2000). Aberrant splicing and altered spatial expression patterns in fruitless mutants of Drosophila melanogaster. Genetics 154: 725-45.

Anand, A., Villella, A., Ryner, L. C., Carlo, T., Goodwin, S. F., Song, H.-J., Gailey, D. A., Hall, J. C., Baker, B. S., and Taylor, B. J. (2001). The sex determination gene fruitless , in addition to controlling male sexual behaviors, has sex-nonspecific vital functions. Genetics, 158: 1569-1595.

Baker, B. S., Taylor, B. T., and Hall, J. C. (2001). Are complex behaviors specified by dedicated regulatory genes? Reasoning from Drosophila. Cell 105: 13-24.

Song, H.-J.,. Goodwin , S. F., Reynaud, E., Carlo, T., Billeter, J.-C., Eric P. Spana, E. P., Perrimon, N., Baker, B. S., and Taylor, B. J. (2002). The fruitless gene is required for the proper formation of axonal tracts in the embryonic CNS of Drosophila. Genetics, in press.

Sexual development and differentiation

Chen, E. H., and Baker, B. S. (1997). Compartmental organization of the Drosophila genital imaginal disks. Development, 124: 205-218.

Keisman, E. L., and Baker, B. S. (2001). The Drosophila sex determination hierarchy modulates wingless and decapentaplegic signaling to sex-specifically deploy dachsund in the genital imaginal disc. Development 128: 1643-1656.

Keisman, E. L., Christiansen, A. E., and Baker, B. S. (2001). The sex determination gene doublesex (dsx) regulates the A/P organizer to direct sex-specific patterns of growth in the Drosophila genital imaginal disc. Developmental Cell, 1: 215-225.

Ahmad, S. M. and Baker, B. S. (2002). Sex-Specific deployment of FGF signaling in Drosophila recruits mesodermal cells into the male genital imaginal disc. Cell, 109, 651-661.

Christiansen, A. E., Keisman, E. L., Ahmad, S. M., and Baker, B. S. (2002). Sex comes in from the cold: the integration of sex and pattern. Trends in Genetics, 18: 510-516.

Arbeitman, M.*, Furlong, E.*, Imam, F.*, Johnson, E.*, Null, B.*, Baker, B. S., Davis, R., Krasnow, M., Scott, M., White, K.P. (2002). A genomic analysis of gene expression during the Drosophila life cycle. Science, 297: 2270-75. (*Co-first authors).

Evolution of sex

Chandler, D., McGuffiin, M. E., Piskur, J., Yao, J., Baker, B. S., and Mattox, W. (1997). Evolutionary conservation of regulatory strategies for the sex determining factor transformer-2. Mol. Cell. Biol.,17: 2908-2919.

Marin, I., and Baker, B. S. (1998). The evolutionary dynamics of sex determination. Science, 281: 1990-1994.

Marin, I., Franke, A., Bashaw, G. J., and Baker, B. S. (1996). Dosage compensation in flies: a regulatory system adapting to chromosome evolution.. Nature, 383: 160-163.

Marin, I., and Baker, B. S. (2000). Origin and evolution of the regulatory gene male-specific lethal 3. Mol. Biol. Evol.17: 1240-1250.

Marin, I., Siegal, M. L. and Baker, B. S. (2000). The evolution of dosage compensation mechanisms. BioEssays, 22: 1106-1114.

RNA splicing

Kim, Young-Yoon, and Baker, B. S. (1993). Studies on the RRM-type RNA binding protein gene family in Drosophila melanogaster using PCR with degenerate primers. Mol. Cell Bio., 13: 174-183.

Kim, Young-Yoon, and Baker, B. S. (1993). The Drosophila gene rbp9 encodes a protein that is a member of a conserved group of putative RNA binding proteins that are nervous system-specific in both flies and humans. J. Neurosci., 13(3): 1045-1056.

Heinrichs, V., and Baker, B. S. (1995). The Drosophila SR protein RBP1 contributes to the regulation of doublesex alternative splicing by recognizing RBP1 RNA target sequences. EMBO, 14: 3987-4000.

Mattox, M., McGuffin, M. E., and Baker, B. S. (1996). A negative feedback mechanism revealed by functional analysis of the alternative isoforms of the Drosophila splicing regulator transformer-2. Genetics 143: 303-314.

Ryner, L. C., Goodwin, S. F., Castrillon, D. H., Anand, A., Villella, A., Baker, B., Hall, J. C., Taylor, B. J., and Wasserman, S. A. (1996). Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene. Cell, 87:1079-1089.

Heinrichs, V., and Baker, B. S. (1997). In vivo analysis of functional domains of the Drosophila alternative splicing factor RBP1. Proc. Natl. Acad. Sci., 94: 115-120.

Chandler, D., McGuffiin, M. E., Piskur, J., Yao, J., Baker, B. S., and Mattox, W. (1997). Evolutionary conservation of regulatory strategies for the sex determining factor transformer-2. Mol. Cell. Biol.,17: 2908-2919.

Heinrichs, V., Ryner, L., and Baker, B. S. (1998). Regulation of fruitless sex-specific 5' splice site selection by transformer and transformer-2. Mol. Cell. Biol.,18: 450-458.

Arbeitman, M., Furlong, E., Imam, F., Johnson, E., Null, B., Baker, B. S., Davis, R., Krasnow, M., Scott, M., White, K.P. (2002). A genomic analysis of gene expression during the Drosophila life cycle. Science, 297: 2270-75. (Co-first authors).