Kaiser Lab Research
About Myxococci Our Research Lab Members Publications Sequence Data Links & Resources  >Other Web Sites  >E-Mail Directory  >Myxo References  >Events Guestbook Last update		Overview Motility S-motility & development (Yvonne Cheng) tgl, pilQ and S motility (Eric Nudleman) Funding	Development Rippling (Roy Welch, Dale Kaiser) dsg (Yvonne Cheng) sigma-54 activators (Lisa Gorski, Thomas Gronewold) devTRS (Anthony Garza) Sporulation (Ellen Licking, Todd Herrington)	Former lab members devTRS (Bryan Julien) sigma-54 and Tn5-lac 4521 (Ingrid Keseler) Pili and social motility (Samuel Wu) tgl, pilQ and S motility (Dan Wall)
		Motility Social motility, sglA (pilQ) and tgl (Dan Wall, Eric Nudleman) Social gliding motility involves group movements of cells on a solid surface and is required for rippling, fruiting body formation and development in M. xanthus. Genetic studies have demonstrated that polar type IV pili are required for S-motility (see above). A similar type of motility has been shown to involve type IV pili in Pseudomonas aeruginosa and Neisseria gonorrhoeae, establishing type IV pili as common component in some forms of bacterial translocation. In M. xanthus, tgl- cells lack S-motility and pili, but can be transiently stimulated for S-motility and pili production by contact with a tgl+ cell. The tgl gene encodes a lipoprotein which contains six tandem tetratricopeptide repeats (TPR) (Rodriguez and Kaiser, 1997b), suggesting Tgl is involved in protein-protein interactions. Evidence suggests that Tgl contact stimulation is greatly enhanced by cell movements, cell alignment, and particularly by end-to-end contacts between cells. The pilQ (sglA) gene product, which belongs to the pIV/PulD outer membrane gated channel family, was shown to be required for Tgl contact stimulation. This result suggests that Tgl is associated with or can be transported through the putative PilQ gated channel. S-motility and development (Yvonne Cheng) To be submitted.