B In proteins, it indicates that the amino acid could be
either Aspartic Acid or Glutamic Acid. Sometimes you can't
tell because of the amide could be hydrolyzed during
purification. backtracking algorithm The process of repeatedly exploring paths until you
encounter the solution. Also called recursion. bacteria Structurally simple, single celled organism, with no
nucleus. bacteriophage Phage - a virus that infects a bacterium. BAC Bacterial artificial chromosome. A circular piece of DNA
that can exist and replicate within a bacteria. BACs are
often used to clone human DNA. balanced polymorphism A polymorphism that is stable over time and is maintained
by balancing selection. balanced selection A selection regime that results in the maintenance of two
or more alleles at a locus in a population (e.g.
overdominance). banding Areas of light and dark staining on chromosomes. basal promoter The position within a eukaryotic promoter where the
initiation complex is assembled. basal rate of transcription The number of productive initiations of transcription
occurring per unit time at a particular promoter. base One of the building blocks of DNA or RNA. The four bases
in DNA are adenine (a), cytosine(C), guanine(G), and
thymine(T). Uracil (U) is used in place of thymine(T) in
RNA. base analog A compound whose structural similarity to one of the
bases in DNA enables it to act as a mutagen. base excision repair a DNA repair process that involves excision and
replacement of an abnormal base. baseless site A position in the DNA molecule where the base component
of the nucleotide is missing. base pair (bp) Two bases (adenine and tymine, or guanine and cytosine)
held together by weak hydrogen bonds. The two strands of DNA
are held together in the shape of a double helix by the
bonds between the base pairs. A "bp" is considered a unit of
measurement of double-stranded DNA length. base sequence The order of nucleotide bases in a DNA or RNA
molecule. base sequence analysis A method, sometimes automated, for determining the base
sequence of DNA or RNA. base stacking The hydrophobic interactions that occur between adjacent
base pairs in a double-stranded DNA molecule. basic domain A type of DNA binding domain. bash A UNIX shell. batch Entrez A feature in Entrez that allows the retrieval of many
sequences at once and saves the sequences to a file on a
local computer. This is particularly useful if you want to
download a set of sequences to analyze locally. A statistical theory which allows you to integrate the
current experimental data with what you knew before the
experiment. B-DNA The most common structural conformation of the DNA double
helix in living cells. beta sheet A common secondary structure of a protein where several
beta strand (or elongated) regions of a protein line up next
to each other to form a flat sheet structure (Monellin
1MON). beta turn A sequence of four amino acids, the second is usually
glycine, which causes a polypeptide to change direction. bifurcation The graphical representation in a phylogenetic tree of an
evolutionary speciation event whereby an ancestral taxon
splits into two. biochemical pathway A network of interacting molecules that is responsible
for a specific biochemical junction, such as a metabolic
pathway or a signal transduction pathway. bioinformatics Refers to the wide range of computational techniques used
to analyze DNA and protein sequences. biological information The information contained in the genome of an organism
and which directs the development and maintenance of that
organism. biotechnology A set of biological techniques developed through basic
research, and now applied to research and product
development. In particular, the use by industry of
recombinant DNA, cell fusion, and new bioprocessing
techniques. bit A single unit of computer memory. It has two states, 0 or
1. bit score A scaled version of an alignment's raw score that
accounts for the statistical properties of the scoring
system used. BLAST Basic Local Alignment Search Tool. A heuristic sequence
comparison algorithm, that is used to search sequence
databases for optimal local alignments to a query. blunt end An end of a double-stranded DNA molecule where both
strands terminate at the same nucleotide position with no
single-stranded extension. blunt end ligation Linking together of two double stranded DNA molecules
which have blunt ends. bootstrapping A statistical method that is often used to estimate the
reproducibility of specific features of phylogenetic
trees. bottleneck A severe reduction in population size. box A short DNA sequence adjacent to or residing within a
gene that performs a regulatory function (e.g., TATA
box) bp Base pair. branch The graphical representation of an evolutionary
relationship in a phylogenetic tree. branch migration A step in the Hollliday model for homologous
recombination involving exchange of polynucleotides between
a pair of recombining double-stranded DNA molecules. browser A program used to access sites on the World Wide Web. B-Tree Balanced Tree. A common data structure for creating
indexes on disk. byte An amount of computer memory that holds a single
character. It is usually 8 bits in length.
B