Featured Articles
Yackle, K., Schwarz, L., Kam, K., Sorokin, J., Huguenard, J.R., Feldman, J.L., Krasnow, M.A. (2017)
Breathing control center neurons that promote arousal in mice. Science 355, 1411-1415.

 

   
Li, P.+, Janczewski, W.A.+, Yackle, K.+, Kam, K., Pagliardini, S., Krasnow, M.A.*, and Feldman, J.L.* (+, co-first authors; *, corresponding authors) (2016)
The peptidergic control circuit for sighing. Nature 530, 293-297.

 

   

Chang, A.J., Ortega, F.E., Riegler, J., Madison, D.V. and Krasnow, M.A. (2015)
Oxygen regulation of breathing through an olfactory receptor activated by lactate. Nature 527, 240-244.

 

   
Kuo, C.S. and Krasnow, M.A. (2015)
Formation of a Neurosensory Organ by Epithelial Cell Slithering.  Cell 163, 394-405.

 

   
Kumar, M.E., Bogard, P.E., Espinoza, F.H., Menke, D.B., Kingsley, D.M., Krasnow, M.A. (2014)
Defining a mesenchymal progenitor niche at single cell resolution. Science 346,
1-9.


 

   
Treutlein, B.+, Brownfield, D.G.+, Wu, A.R., Neff, N.F., Mantalas, G.L., E spinoza, F.H., Desai, T.J.*, Krasnow, M.A.*, and Quake, S.R.*(2014)
Reconstructing lineage hierarchies of the distal lung epithelium using single cell RNA-seq. Nature 509, 371-375.

 

   
Desai, T., Brownfield, D.G., and Krasnow, M.A. (2014)
Alveolar progenitor and stem cells in lung development, renewal and cancer.
Nature 507, 190-194.


 

   
 

Featured Reviews

Ghabrial, A., Luschnig, S., Metzstein, M. and Krasnow, M.A. (2003)
Branching morphogenesis of the Drosophila tracheal system. Annual Review of Cell & Developmental Biology 19, 623-647. pdf

Lubarsky, B., and Krasnow, M.A. (2002) 

Tube morphogenesis, making and shaping biological tubes. Cell 112, 19-28. pdf

Metzger, R. and Krasnow, M.A. (1999)
Genetic control of branching morphogenesis. Science 284, 1635-1639. pdf

 

 

 

Publications

Yackle, K., Schwarz, L., Kam, K., Sorokin, J., Huguenard, J.R., Feldman, J.L., and Krasnow, M.A. (2017) Breathing control center neurons that promote arousal in mice. Science, 355, 1411-1415.

Tan, S.Y.S. and Krasnow, M.A. (2016) Developmental origin of lung macrophage diversity. Development 143, 1318-1327.

Li, P., Janczewski, W.A., Yackle, K., Kam, K., Pagliardini, S., Krasnow, M.A., and Feldman, J.L. (2016) The peptidergic control circuit of sighing. Nature, 530, 293-297.

Chang, A., Ortega, F., Riegler, J., Madison, D., and Krasnow, M.A.(2015) Oxygen control of breathing by an olfactory receptor activated by lactate. Nature, 527, 240-244.

Kuo, C. and Krasnow, M.A. (2015) Formation of a neurosensory organ by epithelial cell slithering. Cell, 163, 394-405.

Peterson, S.J. and Krasnow, M.A.(2015) Subcellular trafficking of FGF controls tracheal invasion of Drosophila flight muscle. Cell 160, 313-323.

Kumar, M.E., Bogard, P.E., Espinoza, F.H., Menke, D.B., Kingsley, D.M., Krasnow, M.A. (2014) Defining a mesenchymal progenitor niche at single cell resolution. Science 346, 1-9. pdf.

Martinez Alanis, D., Chang, D., Akiyama, H., Krasnow, M.A. and Chen, J. (2014) Two nested developmental waves demarcate a compartment boundary in the mouse lung.  Nature Communications 5 (3923), 1-15. pdf. Supplementary Info.

Treutlein, B.+, Brownfield, D.G.+, Wu, A.R., Neff, N.F., Mantalas, G.L., Espinoza, F.H., Desai, T.J.*, Krasnow, M.A.*, and Quake, S.R.* (2014) Reconstructing lineage hierarchies of the distal lung epithelium using single cell RNA-seq.  Nature 509, 371-375, (*, corresponding authors, +, co-first authors). pdf Extended Data. Supplementary Info.

Desai, T., Brownfield, D.G., and Krasnow, M.A. (2014) Alveolar progenitor and stem cells in lung development, renewal and cancer.  Nature 507, 190-194. pdf Extended Data. Supplementary Info.

Chen, F. and Krasnow, M.A. (2014) Progenitor outgrowth from the niche in Drosophila trachea is guided by FGF from decaying branches.  Science 343, 186-189. pdf. Supplementary Info.

Desai, T. and Krasnow, M.A. (2013) Differentiated cells in a back-up role.  Nature 503, 204-205. pdf

Tan, F., Vladar, E., Ma, L., Fuentealba, L., Hoh, R., Espinoza, F.H., Axelrod, J., Alvarez-Buylla, A., Stearns, T., Kintner, C. and Krasnow, M.A. (2013) The proto-oncogene Myb is expressed in post-mitotic epithelial cells and promotes centriole amplification and later steps of the multiciliogenesis program.  Development 140, 4277-4286. pdf

Wang, H. St. Julien, K.R., Stevenson, D.K., Hoffmann, T.J., Witte, J.S., Lazzeroni, L.C., Krasnow, M.A., Quaintance, C.C., Oehlert, J.W., Jelliffe-Pawlowski, L., Gould, J.B., Shaw, G.M., and O’Brodovich, H.M. (2013) A genome-wide association study (GWAS) for bronchopulmonary dysplasia.  Pediatrics 132, 290-297. pdf

St. Julien, K., Jelliffe-Pawlowski, L.L., Shaw, G.M., Stevenson, D.K., O’Brodovich, H.M. and Krasnow, M.A. (2013) High quality genome-wide genotyping from archived dried blood spots without DNA amplification.  PLoS One 8, e64710. pdf Supplementary info.

Chen, J. and Krasnow, M.A. (2012)
Integrin beta 1 suppresses multilayering of a simple epithelium.  PLoS One 7, e52886.

Greif, D., Kumar, M, Lighthouse, J.K., Hum, J., An, A., Ding, L., Red-Horse, M.K., Espinoza, F.H., Olson, L., Offermanns, S., Krasnow, M.A. (2012)
Radial construction of an arterial wall.  Dev Cell 23, 482-493.

Ghabrial, A.S., Levi, B.P. and Krasnow, M.A. (2011)
A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system.  PLoS Genetics 7: e1002087.

Red-Horse, K., Ueno, H., Weissman, I.L., Krasnow, M.A. (2010)
Coronary arteries form by developmental reprogramming of venous cells.  Nature 464, 549-553.

London, N.R., Zhu, W.,  Bozza, F.A., Smith, M.C.P., Greif, D.M., Sorensen L.K., Chen, L., Kaminoh, Y., Chang, A.C., Passi, S.F., Day, C.W., Barnard, D.L., Zimmerman, G.A., Krasnow, M.A., Li, D.Y. (2010)
Targeting Robo4-dependent slit signaling to survive the cytokine storm in sepsis and influenza.  Science Trans Med 2, 1-9.

Weaver, M. and Krasnow, M.A. (2008)
Dual origin of tissue-specific progenitor cells in Drosophila tracheal remodeling.  Science 321,1496.

Babcock, D.T., Fish, G., Wang, Y., Krasnow, M.A., and Galko, M.J. (2008) Circulating blood cells function as a surveillance system for damaged tissue in Drosophila larvae.  PNAS 105, 10017-10022.

Metzger, R., Klein, O.D., Martin, G.R., and Krasnow, M.A. (2008) 
The branching programme of mouse lung development.  Nature 453, 745-750.

Metzstein, M.M. and Krasnow, M.A. (2006)
Functions of the nonsense-mediated RNA decay pathway in Drosophila development.  PLoS Genetics 2, 2143-2154.

Ghabrial, A. and Krasnow, M.A. (2006)
Social interactions among epithelial cells during tracheal branching morphogenesis. Nature 441: 746-749. pdf

Levi, B., Ghabrial, A. and Krasnow, M.A. (2006)
Drosophila talin and integrin genes are required for maintenance of tracheal terminal branches and luminal organization. Development 133: 2383-2393. pdf

Gerber, A.P., Luschnig, St., Krasnow, M.A., Brown, P.O., and Herschlag, D. (2006)
Genome-wide identification of mRNAs associated with the translational regulator PUMILIO in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 103: 4487-4492. pdf

Jarvis, L., Toering, S., Simon, M., Krasnow, M.A., and Smith-Bolton, R. (2006)
Sprouty proteins are in vivo targets of Corkscrew/SHP-2 tyrosine phosphatases. Development 133: 1133-1142. pdf

Luschnig, S., Batz, T., Armbruster, K., and Krasnow, M.A. (2006)
Serpentine and vermiform encode matrix proteins with chitin binding and deacetylation that limit tracheal tube length in Drosophila. Current Biology 16: 186-194. pdf

Devine, W.P., Lubarsky, B., Shaw, K., Luschnig, S., Messina, L., and Krasnow, M.A. (2005)
Requirement for chitin biosynthesis in epithelial tube morphogenesis. Proc. Natl. Acad. Sci. USA 102: 17014-17019. pdf

Galko, M. and Krasnow, M.A. (2004)
Cellular and genetic analysis of wound healing in Drosophila larvae. Public Library of Science Biology 2(8): e239, 1114-1126. pdf

Ghabrial, A., Luschnig, S., Metzstein, M. and Krasnow, M.A. (2003)
Branching morphogenesis of the Drosophila tracheal system. Annual Review of Cell & Developmental Biology 19, 623-647. pdf

Lubarsky, B., and Krasnow, M.A. (2002)
Tube morphogenesis: making and shaping biological tubes. Cell 112, 19-28. pdf

Arbeitman, M.N., Furlong, E.E., Imam, F., Johnson, E., Null, B.H., Baker, B.S., Krasnow, M.A., Scott, M.P., Davis, R.W., and White, K.P. (2002)
Gene expression during the life cycle of Drosophila melanogaster. Science 297, 2270-2275. pdf

Krasnow, M.A. and Nelson, W.J. (2002)
Tube morphogenesis. Trends in Cell Biology 12 (8), 351. pdf

Cho, N.K., Keyes, L., Johnson, E., Heller, J., Ryner, L., Karim, F., and Krasnow, M.A. (2002)
Developmental control of blood cell migration by the Drosophila VEGF pathway. Cell 108, 865-876. pdf

Shim, K., Blake, K., Jack, J. and Krasnow, M.A. (2001)
The Drosophila ribbon gene encodes a nuclear BTB domain protein that promotes epithelial migration and morphogenesis. Development 128, 4923-4933. pdf

Guillemin, K., Williams, T., and Krasnow, M.A. (2001)
A nuclear lamin is required for cytoplasmic organization and egg polarity in Drosophila. Nature Cell Biology 3, 848-851. pdf

Lee, S. H., Schloss, D.J., Jarvis, L., Krasnow, M.A., and Swain, J.L. (2001) Inhibition of angiogenesis by a mouse Sprouty protein. Journal of Biological Chemistry 276 (6), 4128-4133. pdf

Beitel, G. J. and Krasnow, M.A. (2000)
Genetic control of epithelial tube size in the Drosophila tracheal system. Development 127, 3271- 3282. pdf

Kornberg, T. B. and Krasnow, M.A. (2000)
The Drosophila genome sequence: Implications for biology and medicine. Science 287, 2218-2220. pdf

Jarecki, J., Johnson, E. and Krasnow, M.A. (1999)
Oxygen regulation of airway branching in Drosophila is mediated by Branchless FGF. Cell 99, 211-220 .pdf

Minowada, G., Jarvis, L.A., Chi, C.L., Neubüser, A. , Sun, X., Hacohen, N., Krasnow, M.A., and Martin, G.R. (1999)
Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed. Development 126, 4465-4475. pdf

Metzger, R. and Krasnow, M.A. (1999)
Genetic control of branching morphogenesis. Science 284, 1635-1639. pdf

Kramer, S., Okabe, M., Hacohen, N., Krasnow, M.A., and Hiromi, Y. (1999)
Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila. Development 126, 2515-2525. pdf

Imam, F., Sutherland, D., Huang, W., and Krasnow, M.A. (1999)
Stumps, a Drosophila gene required for FGF-directed migrations of tracheal and mesodermal cells. Genetics 152, 307-318. pdf

Englund, C., Uv, A.E., Cantera, R., Mathies, L.D., Krasnow, M.A., and Samakovlis, C. (1999)
adrift, a novel bnl-induced Drosophila gene required for tracheal pathfinding into the CNS. Development 126(7):1505-14. pdf

Hacohen, N., Kramer, S. , Sutherland, D., Hiromi, Y, and Krasnow, M.A. (1998)
Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. Cell 92, 253-263. pdf

Krasnow, M.A. (1998)
Genes that control organ form: Lessons from bone and branching morphogenesis. Cold Spring Harbor Symposia on Quantitative Biology, Cold Spring Harbor Press (Cold Spring Harbor, New York), pp. 235-240. pdf

Guillemin, K. and Krasnow, M.A. (1997)
The hypoxic response: Huffing and HIFing. Cell 89, 9-12. pdf

Sutherland, D., Samakovlis, C., and Krasnow, M.A. (1996)
Branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching. Cell 87, 1091-1101. pdf

Lee, T., Hacohen, N., Krasnow, M.A., and Montell, D.J. (1996)
Regulated Breathless receptor tyrosine kinase activity required to pattern cell migration and branching in the Drosophila tracheal system. Genes and Development 10, 2912-2921. pdf

Samakovlis, C., Manning, G., Hacohen, N. and Krasnow, M.A. (1996)
Genetic control of epithelial tube fusion during Drosophila tracheal development. Development 122, 3531-3526. pdf

Montagne, J., Groppe, J., Guillemin, K., Krasnow, M.A., Gehring, W.J., and Affolter, M. (1996)
The Drosophila serum response factor homolog is required for formation of intervein tissue of the wing and is allelic to blistered. Development 122, 2589-2597. pdf

Guillemin, K., Groppe, J., Ducker, K., Treisman, R., Hafen, E., Affolter, M., and Krasnow, M.A. (1996).
The pruned gene encodes the Drosophila serum response factor and regulates cytoplasmic outgrowth during terminal branching of the tracheal system. Development 122, 1353-1362. pdf

Samakovlis, C., Hacohen, N., Manning, G., Sutherland, D., Guillemin, K. and Krasnow, M.A. (1996).
Development of the Drosophila tracheal system occurs by a series of morphologically distinct but genetically coupled branching events. Development 122, 1395-1407. pdf

Van Gelder, R.N., and Krasnow, M.A. (1996).
Partners in time. Current Biology 6, 244-246. pdf

Van Gelder, R.N., Bae, H., Palazzolo, M.J., and Krasnow, M.A. (1995).
Extent and character of circadian gene expression in Drosophila melanogaster: identification of twenty oscillating mRNAs in the fly head. Current Biology 5, 1424-1436. pdf

Van Gelder, R.N., and Krasnow, M.A. (1996).
A novel circadianly expressed Drosophila melanogaster gene dependent on the period gene for its rhythmic expression. EMBO Journal 15, 1625-1631.

Johnson, F.B., Parker, E., and Krasnow, M.A. (1995).
Extradenticle protein is a selective cofactor for the Drosophila homeotics: Role of the homeodomain and YPWM amino acid motif in the interaction. Proc. Natl. Acad. Sci. USA 92, 739-743. pdf

Cumberledge, S. and Krasnow, M.A. (1994).
Preparation and analysis of pure cell populations from Drosophila. In Methods in Cell Biology, vol. 44 (Eds. E. Fyrberg and L. Goldstein), Academic Press, pp. 143-159. pdf

Saffman, E.E. and Krasnow, M.A. (1994).
A differential response element for the homeotics at the Antennapedia P1 promoter of Drosophila. Proc. Natl. Acad. Sci. USA 91, 7420-7424 .pdf

Manning, G. and Krasnow, M.A. (1993).
Development of the Drosophila tracheal system. In The Development of Drosophila melanogaster (Eds. M. Bate and A. Martinez Arias), Cold Spring Harbor Press (Cold Spring Harbor, New York), pp. 609-685.

Cumberledge, S. and Krasnow, M.A. (1993).
Intercellular signalling in Drosophila segment formation reconstructed in vitro. Nature 363, 549-52.

Johnson, F.B. and Krasnow, M.A. (1992).
Differential regulation of transcription preinitiation complex assembly by activator and repressor homeodomain proteins. Genes and Development 6, 2177-89. pdf

Krasnow, M.A., Cumberledge, S., Manning, G., Herzenberg, L. and Nolan, G. (1991).
Whole animal cell sorting of Drosophila embryos. Science 251, 81-85. pdf

Johnson, F.B. and Krasnow, M.A. (1990).
Stimulation of transcription by an Ultrabithorax protein in vitro. Genes and Development 4, 1044-52. pdf

Parker, E., Johnson, B., Saffman, E.E. and Krasnow, M.A. (1989). Transcriptional regulation by homeotic gene products in cultured Drosophila cells and in vitro. In Current Communications in Molecular Biology, Cold Spring Harbor Press (Cold Spring Harbor, New York), pp.23-29.

Winslow, G.M., Hayashi, S., Krasnow, M., Hogness, D.S. and Scott, M.P. (1989).
Transcriptional activation by the Antennapedia and fushi tarazu proteins in cultured Drosophila cells. Cell 57, 1017-30. pdf

Krasnow, M.A., Saffman, E.E., Kornfeld, K. and Hogness, D.S. (1989). Transcriptional activation and repression by Ultrabithorax proteins in cultured Drosophila cells. Cell 57, 1031-43. pdf

Beachy, P.A., Krasnow, M.A., Gavis, E.R., and Hogness, D.S. (1988).
An Ultrabithorax protein binds sequences near its own and the Antennapedia P1 promoters. Cell 55, 1069-81.

Benjamin, H., Matzuk, M., Krasnow, M.A. and Cozzarelli, N.R. (1985). Recombination site selection by Tn3 resolvase: Topological tests of a tracking mechanism. Cell 40, 147-58.

Cozzarelli, N.R., Krasnow, M.A., Gerrard, S.B., and White, J.H. (1984).
A topological treatment of recombination and topoisomerases. Cold Spring Harbor Symposia on Quantitative Biology XLIX, 383-400.

Krasnow, M.A., Stasiak, A., Spengler, S.J., Dean, F., Koller, T., and Cozzarelli, N.R. (1983).
Determination of the absolute handedness of knots and catenanes of DNA. Nature 304, 559-560.

Krasnow, M.A., Matzuk, M.M., Dugan, J.M., Benjamin, H.W. and Cozzarelli, N.R. (1983).
Site-specific recombination by Tn3 resolvase: models for pairing of recombination sites. In Mechanisms of DNA Replication and Recombination. UCLA Symposia on Molecular and Cellular Biology, New Series Volume X, ed. Nicholas R. Cozzarelli, Alan R. Liss, Inc. (New York, NY), pp. 637-659.

Dean, F., Krasnow, M.A., Otter, R., Matzuk, M.M., Spengler, S.J., and Cozzarelli, N.R. (1983).
Escherichia coli type 1 topoisomerases: identification, mechanisms, and role in recombination. Cold Spring Harbor Symposia on Quantitative Biology XLVII, 769-777.

Krasnow, M.A. and Cozzarelli, N.R. (1983).
Site-specific relaxation and recombination by the Tn3 resolvase: recognition of the DNA path between oriented res sites. Cell 32, 1313-1324.

Krasnow, M.A. and Cozzarelli, N.R. (1982).
Catenation of DNA rings by topoisomerases: mechanism of control by spermidine. Journal of Biological Chemistry 257, 2687-2693 .pdf