Department of
Microbiology and Immunology.
Stanford University School of Medicine
Faculty Research Interests
To view a given faculty member's research
interests
and a sample of recent publications, click on the appropriate name
below.
.
-
Ann
Arvin
Molecular virology of and immunity to
varicella-zoster
virus (VZV); virus/target cell interactions in the pathogenesis of VZV
infection in the natural human host and in the SCID-hu model; analysis
of the T-cell-mediated host response to major viral glycoproteins and
to
viral structural and regulatory proteins.
- Helen
Blau
Molecular and cellular mechanisms that control
muscle and neuronal growth, stem cell biology, differentiation, and
tumorigenicity;
gene therapy for angiogenesis; vector design and treatment of
cardiovascular
disease and cancer.
-
Matt
Bogyo
Chemical biological approaches to the study of
protease function in the human parasites, Toxoplasma gondii and
Plasmodium
falciparum. Emphasis on the role of proteases in protein trafficking,
host
cell invasion and rupture and cell cycle regulation.
- John
Boothroyd
Biology and genetics of the protozoan parasite
Toxoplasma, with emphasis on gene regulation, protein trafficking,
invasion,
and developmental biology.
- Chang-Zheng
Chen
Genetic networks controlled by regulatory
RNAs, such as microRNAs and small interfering RNAs, and the roles of
these RNAs in modulating hte development, function and pathogenesis of
vertebrate immune systems.
-
Yueh-hsiu
Chien
Genetic and molecular analyses of bacterial
infection
on host adaptive immune response; the effect of Yersinia infection on T
and B cell responses; development and function of gd T cells.
- Chris
Contag
Molecular mechanisms of pathogenesis and host
response to insult using in vivo cellular and molecular imaging to
reveal
biological processes in living animal models of disease. Emphases on
gene
expression and cell migration in vivo.
- Mark
Davis
Mechanisms of T-lymphocyte recognition and
differentiation;
particular interests in T-cell receptor structure, function, thymic
selection,
and dynamics of cell surface molecules during T-cell recognition.
- Stanley
Falkow
Genetic and molecular mechanisms of microbial
pathogenicity; Salmonella exploits caspase-1 to colonize peyeris
patches
in a murine typhoid model; OmpR regulates the two-component system
SsrA-SsrB
in Salmonella pathogenicity island 2.
- Steve
Galli
Regulation of mast cell and basophil
development,
phenotype, and function; roles of mast cells in innate and acquired
immunity
and inflammation; pathogenesis of allergic inflammation; development of
new in vivo models to pursue these goals.
- K.
Chris
Garcia
Structural biology of cell surface receptor
recognition
and activation; X-ray crystallographic and biophysical analysis of
proteins
implicated in autoimmunity, natriuresis, and host-pathogen interactions.
- Harry
Greenberg
Gene coding assignments for rotavirus, with
specific
emphasis on the molecular determinants of virulence, host range, and
immunity;
immunity to hepatitis C virus.
- Peter
Jackson
Control of the mitotic cell cycle by
cyclin-dependent
kinases and ubiquitin ligases; biochemical, enzymological, and
structural
studies of substrate recognition and ubiquitin chain formation
mechanisms
for E3 ubiquitin ligases; identification of new substrates and
regulators
of ubiquitination processes by proteomic/mass spectrometric methods.
- Karla
Kirkegaard
Molecular genetics and biochemistry of genome
replication of RNA viruses and viral subversion of protein secretory
apparatus
during infection of human cells.
- A.C.
Matin
Drug resistance in bacteria and their biofilms;
stress response under zero gravity; mechanisms of redox homoeostasis;
biomolecular
engineering of bacterial bioremediation capability.
- Hugh
McDevitt
Structure-function analysis of H2 and HLA-D
region
gene products; how these proteins regulate the immune response and
predispose
to autoimmunity; development of methods to selectively alter Ia/DR
function
in vivo.
- Ed
Mocarski
Molecular biology of herpesviruses, with
emphasis
on cytomegaloviruses; construction of viral mutants, identification of
cis and trans DNA replication functions, isolation of viral genes and
regulatory
signals, and identification of genes involved in latency and
pathogenesis.
- Garry
Nolan
Molecular virology of HIV-1 transcriptional
regulation,
with special emphasis on macrophage and T-cell regulators and NF-kB,
IkB,
and NFAT Rel components; retroviral libraries for complementation
cloning
of signaling molecules in apoptosis and T-cell biology; gene therapy
vectors
and creation of intracellular protein machines.
- Peter
Parham
Regulation of cytotoxic T cell and natural
killer
cells by MHC class I polymorphisms, with an emphasis on the diversity
of
MHC class I in human populations and comparisons in other species.
- Charles
Prober
Conduct of seroepidemiologically based studies
of HSV-2 infections, with special emphasis on gestational and neonatal
infections; humoral and cellular immunologic evaluations of human hosts
to determine the critical factors relevant to the acquisition and
transmission
of HSV-2 infections preliminary to vaccine studies; evaluation of
antiviral
therapies, with special emphasis on the management of herpesvirus
infections.
- David
Relman
Molecular, genome-wide analysis of
pathogen?host
cell interactions; adherence and colonization mechanisms of Bordetella
sp.; pathogen discovery by means of cultivation-independent molecular
methods;
exploration of human microbial ecology.
- Peter
Sarnow
Molecular biology of RNA virus-host
interactions;
mechanism of internal initiation of protein synthesis in viral and
cellular
mRNA.
- David
Schneider
Analysis of innate immunity and host pathogen
interactions; development of lab models for malaria, tuberculosis and
other
intracellular pathogens.
- Gary
Schoolnik
Pathogenesis of M. tuberculosis; pathogenesis
of enteropathogenic E. coli; environmental persistence of V. cholerae
in
environmental habitats.
- Upinder
Singh
Genetic and genomic studies of protozoan
parasites
Entamoeba and Toxoplasma with an emphasis on host-pathogen
interactions,
pathogenesis, and developmental biology.
- Man-Wah
Tan
Genetics and genomics dissection of
host-pathogen
interactions using a multipathogen C. elegans pathogenesis system;
genetics
and molecular analyses of signaling pathways in host innate immune
response.
- Julie
Theriot
Cell biology of interactions between infectious
bacteria and the human host cell actin cytoskeleton; actin-based
motility
of bacterial pathogens.
- Lucy
Tompkins
Molecular pathogenic studies of Legionella,
Helicobacter,
and Campylobacter; genetic and molecular studies to characterize the
host-parasite
interaction. Helicobacter pylori attachment to gastric cells induces
cytoskeletal
rearrangements and tyrosine phosphorylation of host cell proteins.
Induction
of host signal transduction pathways by Helicobacter pylori.
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and Immunology Home Page
photo credits:
Top right: Vacuole containing
Toxoplasma
tachyzoites inside a fibroblast. Manel Camps (Boothroyd Lab)