Microbiology and Immunology.
Stanford University School of Medicine
Faculty Research Interests
To view a given faculty member's research
and a sample of recent publications, click on the appropriate name
Molecular virology of and immunity to
virus (VZV); virus/target cell interactions in the pathogenesis of VZV
infection in the natural human host and in the SCID-hu model; analysis
of the T-cell-mediated host response to major viral glycoproteins and
viral structural and regulatory proteins.
Molecular and cellular mechanisms that control
muscle and neuronal growth, stem cell biology, differentiation, and
gene therapy for angiogenesis; vector design and treatment of
disease and cancer.
Chemical biological approaches to the study of
protease function in the human parasites, Toxoplasma gondii and
falciparum. Emphasis on the role of proteases in protein trafficking,
cell invasion and rupture and cell cycle regulation.
Biology and genetics of the protozoan parasite
Toxoplasma, with emphasis on gene regulation, protein trafficking,
and developmental biology.
Genetic networks controlled by regulatory
RNAs, such as microRNAs and small interfering RNAs, and the roles of
these RNAs in modulating hte development, function and pathogenesis of
vertebrate immune systems.
Genetic and molecular analyses of bacterial
on host adaptive immune response; the effect of Yersinia infection on T
and B cell responses; development and function of gd T cells.
Molecular mechanisms of pathogenesis and host
response to insult using in vivo cellular and molecular imaging to
biological processes in living animal models of disease. Emphases on
expression and cell migration in vivo.
Mechanisms of T-lymphocyte recognition and
particular interests in T-cell receptor structure, function, thymic
and dynamics of cell surface molecules during T-cell recognition.
Genetic and molecular mechanisms of microbial
pathogenicity; Salmonella exploits caspase-1 to colonize peyeris
in a murine typhoid model; OmpR regulates the two-component system
in Salmonella pathogenicity island 2.
Regulation of mast cell and basophil
phenotype, and function; roles of mast cells in innate and acquired
and inflammation; pathogenesis of allergic inflammation; development of
new in vivo models to pursue these goals.
Structural biology of cell surface receptor
and activation; X-ray crystallographic and biophysical analysis of
implicated in autoimmunity, natriuresis, and host-pathogen interactions.
Gene coding assignments for rotavirus, with
emphasis on the molecular determinants of virulence, host range, and
immunity to hepatitis C virus.
Control of the mitotic cell cycle by
kinases and ubiquitin ligases; biochemical, enzymological, and
studies of substrate recognition and ubiquitin chain formation
for E3 ubiquitin ligases; identification of new substrates and
of ubiquitination processes by proteomic/mass spectrometric methods.
Molecular genetics and biochemistry of genome
replication of RNA viruses and viral subversion of protein secretory
during infection of human cells.
Drug resistance in bacteria and their biofilms;
stress response under zero gravity; mechanisms of redox homoeostasis;
engineering of bacterial bioremediation capability.
Structure-function analysis of H2 and HLA-D
gene products; how these proteins regulate the immune response and
to autoimmunity; development of methods to selectively alter Ia/DR
Molecular biology of herpesviruses, with
on cytomegaloviruses; construction of viral mutants, identification of
cis and trans DNA replication functions, isolation of viral genes and
signals, and identification of genes involved in latency and
Molecular virology of HIV-1 transcriptional
with special emphasis on macrophage and T-cell regulators and NF-kB,
and NFAT Rel components; retroviral libraries for complementation
of signaling molecules in apoptosis and T-cell biology; gene therapy
and creation of intracellular protein machines.
Regulation of cytotoxic T cell and natural
cells by MHC class I polymorphisms, with an emphasis on the diversity
MHC class I in human populations and comparisons in other species.
Conduct of seroepidemiologically based studies
of HSV-2 infections, with special emphasis on gestational and neonatal
infections; humoral and cellular immunologic evaluations of human hosts
to determine the critical factors relevant to the acquisition and
of HSV-2 infections preliminary to vaccine studies; evaluation of
therapies, with special emphasis on the management of herpesvirus
Molecular, genome-wide analysis of
cell interactions; adherence and colonization mechanisms of Bordetella
sp.; pathogen discovery by means of cultivation-independent molecular
exploration of human microbial ecology.
Molecular biology of RNA virus-host
mechanism of internal initiation of protein synthesis in viral and
Analysis of innate immunity and host pathogen
interactions; development of lab models for malaria, tuberculosis and
Pathogenesis of M. tuberculosis; pathogenesis
of enteropathogenic E. coli; environmental persistence of V. cholerae
Genetic and genomic studies of protozoan
Entamoeba and Toxoplasma with an emphasis on host-pathogen
pathogenesis, and developmental biology.
Genetics and genomics dissection of
interactions using a multipathogen C. elegans pathogenesis system;
and molecular analyses of signaling pathways in host innate immune
Cell biology of interactions between infectious
bacteria and the human host cell actin cytoskeleton; actin-based
of bacterial pathogens.
Molecular pathogenic studies of Legionella,
and Campylobacter; genetic and molecular studies to characterize the
interaction. Helicobacter pylori attachment to gastric cells induces
rearrangements and tyrosine phosphorylation of host cell proteins.
of host signal transduction pathways by Helicobacter pylori.
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Top right: Vacuole containing
tachyzoites inside a fibroblast. Manel Camps (Boothroyd Lab)