Selena Sagan

Postdoctoral Fellow
Ph.D. Microbiology & Immunology, University of Ottawa, Canada
B.Sc. Microbiology & Immunology (Minor: Pharmacology), McGill University, Canada

 

Fellowships
Natural Sciences and Engineering Research Council (NSERC) of Canada Post-Doctoral Fellowship
National Canadian Research Training Program in Hepatitis C (NCRTP-HepC) Post-Doctoral Trainee


Project
Investigating the role of miR-122 in the life cycle of Hepatitis C virus

 

 

Publications
Sagan SM, Rouleau Y, Leggiadro C, Supekova L, Schultz PG, Su AI, Pezacki JP. (2006) The Influence of Cholesterol and Lipid Metabolism on Host Cell Structure and Hepatitis C Virus Replication. Biochem. Cell Biol. 84 (1):67-69. [Link]

Rakic B, Sagan SM, Noestheden M, Belanger S, Nan X, Evans CL, Xie XS, Pezacki JP. (2006) Peroxisome Proliferator-activated Receptor α/γ Antagonism Inhibits Hepatitis C Virus Replication Through Post-transcriptional Effects. Chem. Biol. 13 (1):23-30. [Link]

Cheng J, Sagan SM, Assem N, Koukiekolo R, Goto NK, Pezacki JP. (2007) Stabilized recombinant suppressors of RNA silencing: Functional effects of linking monomers of Carnation Italian Ringspot virus p19. Biochim. Biophys. Acta. 1774 (12):1528-1535. [Link]

Koukiekolo R, Sagan SM, Pezacki JP. (2007) Effects of pH and salt concentration on the siRNA binding actitivy of the RNA silencing suppressor protein p19. FEBS Lett. 581 (16):3051-3056. [Link]

Sagan SM, Koukiekolo R, Rodgers E, Goto NK, Pezacki JP. (2007) Inhibition of siRNA binding to a p19 viral suppressor of RNA silencing by cysteine alkylation. Angew. Chem. Int. Ed. Engl. 46(12):2005-2009. [Link]

Davis M, Sagan SM, Pezacki JP, Evans DJ, Simmonds P. (2008) Bioinformatic and Physical Characterisation of Genome-Scale Ordered RNA Structure (GORS) in Mammalian RNA Viruses. J. Virol. 82 (23):11824-11836. [Link]

Sagan SM, Cheng J, Jakubek Z, Pezacki JP. (2008) Fluorescence anisotropy studies of the dissociation constants for the protein-RNA interactions of Carnation Italian Ringspot Virus p19 with microRNAs. Biochemistry. 47(31):8130-8138.

Lyn RL, Kennedy DC, Sagan SM, Blais DR, Rouleau Y, Pegoraro A, Xie XS, Stolow A Pezacki JP. (2009) Direct imaging of the disruption of hepatitis C virus replication complexes by inhibitors of lipid metabolism. Virology 394 (1): 130-142. [Link]

Koukiekolo R, Jakubek ZJ, Cheng J, Sagan SM, Pezacki JP. (2009) Studies of a viral suppressor of RNA silencing p19-CFP fusion protein: a FRET-based probe for sensing double-stranded fluorophore tagged small RNAs. Biophys Chem. 43 (3):166-169. [Link]

Cheng J, Koukiekolo R, Kieliszkiewicz K, Sagan SM, Pezacki JP. (2009) Cysteine residues of Carnation Italian ringspot virus p19 suppressor of RNA silencing maintain global structural integrity and stability for siRNA binding. Biochim. Biophys Acta. 1794 (8):1197-1203. [Link]

Pezacki JP, Sagan SM, Tonary AM, Rouleau Y, Belanger S, Supekova L, Su AI. (2009) Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus. BMC Chem. Biol. 16(9):2. [Link]

Sagan SM, Nasheri N, Luebbert C, Pezacki JP. Target site accessibility in Hepatitis C virus RNA. Submitted for Publication.


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