J Mol Biol 135: 581-93 (1979)[80140512]
Highly-repeated satellite DNAs often consist of mixtures of DNAs with
closely related repeating sequences. By cloning individual molecules
we have resolved the 1.705 g/cm3 satellite DNA of Drosophila
melanogaster into two distinct components:
poly[d(A-A-G-A-G)/(T-T-C-T-C)] and
poly[d(A-A-G-A-G-A-G)/(T-T-C-T-C-T-C)]. The presence of two
distinct sequences within this physically homogeneous satellite DNA
had not previously been detected by standard physical, chemical, or
sequencing techniques. Both cloning and direct sequence analysis
suggest that the five-base-pair and seven-base-pair repeating units
reside on separate molecules and are not interspersed with each
other.
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