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in Biocomputing: Informatics and Genome Projects, D. W. Smith (Ed). Academinc Press pp. 269-306

Computational Simulations of Biological Systems

A. R. Galper & D. L. Brutlag

Department of Biochemistry,and the Section on Medical Informatics, Stanford University School of Medicine, Stanford California 94305-5307.

This final chapter describes early projects to simulate biological systems using
data and knowledge available from genomic analyses and from other sources. We
discuss the need for simulations that span multiple levels of biological abstraction,
from the molecule to the organism to the ecosystem, and we describe methods
that permit the modeling of biological entities at each level. We also review recent
research results in biological simulation. We conclude with a discussion of the state
of the field.

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