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In Mechanisms of DNA Replication adn Recombination, UCLA Symposia on Molecular and Cellular Biology, New Series, Vol 10., N. R. Cozzarelli, Ed., ALan R. Liss, Inc. New York 1983

Recognition of Supercoiled DNA by Drosophila Topoisomerase II

N. Osheroff, E. R. Shelton & D. L. Brutlag

The type II topoisornerase from the fly, Drosophila melanogaster, is able to distinguish the topological structure of DNA and interacts preferentially with negatively supercoiled over relaxed molecules. Furthermore, this study indicates that the enzyme recognizes points of helix-helix proximity found in supercoiled DNA and upon binding, condenses its nucleic acid substrate.

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