Recent Publications

Kim J, Lu C, Srinivasan S, Awe S, Brehm A, Fuller MT. (2017). Blocking promiscuous activation at cryptic promoters directs cell type-specific gene expression. Science

Fuller MT (2016). Differentiation in Stem Cell Lineages and in Life: Explorations in the Male Germ Line Stem Cell Lineage. Curr. Top. Dev. Biol.

Lu, C., and Fuller, M.T. (2015). Recruitment of Mediator Complex by Cell Type and Stage-Specific Factors Required for Tissue-Specific TAF Dependent Gene Activation in an Adult Stem Cell Lineage. PLoS Genet 11, e1005701.

Baker, C.C., Gim, B.S., and Fuller, M.T. (2015). Cell type-specific translational repression of Cyclin B during meiosis in males. Development (Cambridge, England) 142, 3394-3402.

Shields, A.R., Spence, A.C., Yamashita, Y.M., Davies, E.L., and Fuller, M.T. (2014). The actin-binding protein profilin is required for germline stem cell maintenance and germ cell enclosure by somatic cyst cells. Development (Cambridge, England) 141, 73-82.

Morillo Prado, J.R., Srinivasan, S., and Fuller, M.T. (2013). The histone variant His2Av is required for adult stem cell maintenance in the Drosophila testis. PLoS genetics 9, e1003903.

Lu, C., Kim, J., and Fuller, M.T. (2013). The polyubiquitin gene Ubi-p63E is essential for male meiotic cell cycle progression and germ cell differentiation in Drosophila. Development (Cambridge, England) 140, 3522-3531.

Morillo Prado, J.R., Chen, X., and Fuller, M.T. (2012). Polycomb group genes Psc and Su(z)2 maintain somatic stem cell identity and activity in Drosophila. PloS one 7, e52892.

Davies, E.L., Lim, J.G., Joo, W.J., Tam, C.H., and Fuller, M.T. (2013). The transcriptional regulator lola is required for stem cell maintenance and germ cell differentiation in the Drosophila testis. Developmental biology 373, 310-321.

Insco, M.L., Bailey, A.S., Kim, J., Olivares, G.H., Wapinski, O.L., Tam, C.H., and Fuller, M.T. (2012). A self-limiting switch based on translational control regulates the transition from proliferation to differentiation in an adult stem cell lineage. Cell stem cell 11, 689-700.

Lim, J.G., and Fuller, M.T. (2012). Somatic cell lineage is required for differentiation and not maintenance of germline stem cells in Drosophila testes. Proceedings of the National Academy of Sciences of the United States of America 109, 18477-18481.

Giansanti M.G., Fuller M.T. (2012). What Drosophila spermatocytes tell us about the mechanisms underlying cytokinesis. Cytoskeleton (Hoboken). 2012 Nov;69(11):869-81.

Srinivasan, S., Mahowald, A.P., and Fuller, M.T. (2012). The receptor tyrosine phosphatase Lar regulates adhesion between Drosophila male germline stem cells and the niche. Development (Cambridge, England) 139, 1381-1390.

Szafer-Glusman, E., Fuller, M.T., and Giansanti, M.G. (2011). Role of Survivin in cytokinesis revealed by a separation-of-function allele. Molecular biology of the cell 22, 3779-3790.

Spradling A., Fuller M.T., Braun R.E., Yoshida S. (2011). Germline stem cells. Cold Spring Harb Perspect Biol. 2011 Nov 1;3(11):a002642.

Chen X., Lu C., Morillo Prado J.R., Eun S.H., Fuller M.T. (2011) Sequential changes at differentiation gene promoters as they become active in a stem cell lineage. Development. 2011 Jun;138(12):2441-50.

Insco, M.L., Leon, A., Tam, C.H., McKearin, D.M., and Fuller, M.T. (2009). Accumulation of a differentiation regulator specifies transit amplifying division number in an adult stem cell lineage. Proceedings of the National Academy of Sciences of the United States of America 106, 22311-22316.

Robinett, C.C., Giansanti, M.G., Gatti, M., and Fuller, M.T. (2009). TRAPPII is required for cleavage furrow ingression and localization of Rab11 in dividing male meiotic cells of Drosophila. Journal of cell science 122, 4526-4534.

Davies, E.L., and Fuller, M.T. (2008). Regulation of self-renewal and differentiation in adult stem cell lineages: lessons from the Drosophila male germ line. Cold Spring Harbor symposia on quantitative biology 73, 137-145.

Li V.C., Davis J.C., Lenkov K., Bolival B., Fuller M.T., Petrov D.A. (2009) Molecular evolution of the testis TAFs of Drosophila. Mol Biol Evol. 2009 May;26(5):1103-16.

Szafer-Glusman, E., Giansanti, M.G., Nishihama, R., Bolival, B., Pringle, J., Gatti, M., and Fuller, M.T. (2008). A role for very-long-chain fatty acids in furrow ingression during cytokinesis in Drosophila spermatocytes. Curr Biol 18, 1426-1431.

Yamashita Y.M., Fuller M.T. (2008) Asymmetric centrosome behavior and the mechanisms of stem cell division. J Cell Biol. 2008 Jan 28;180(2):261-6.

Baker, C.C., and Fuller, M.T. (2007). Translational control of meiotic cell cycle progression and spermatid differentiation in male germ cells by a novel eIF4G homolog. Development (Cambridge, England) 134, 2863-2869.

Fuller, M.T., and Spradling, A.C. (2007). Male and female Drosophila germline stem cells: two versions of immortality. Science (New York, NY 316, 402-404.

Yamashita, Y.M., Mahowald, A.P., Perlin, J.R., and Fuller, M.T. (2007). Asymmetric inheritance of mother versus daughter centrosome in stem cell division. Science (New York, NY 315, 518-521.

Clarke, M.F., and Fuller, M. (2006). Stem cells and cancer: two faces of eve. Cell 124, 1111-1115.

Yamashita, Y.M., and Fuller, M.T. (2005). Asymmetric stem cell division and function of the niche in the Drosophila male germ line. International journal of hematology 82, 377-380.

Chen, X., Hiller, M., Sancak, Y., and Fuller, M.T. (2005). Tissue-specific TAFs counteract Polycomb to turn on terminal differentiation. Science (New York, NY 310, 869-872.

Yamashita, Y.M., Fuller, M.T., and Jones, D.L. (2005). Signaling in stem cell niches: lessons from the Drosophila germline. Journal of cell science 118, 665-672.

Hiller M., Chen X., Pringle M.J., Suchorolski M., Sancak Y., Viswanathan S., Bolival B., Lin T.Y., Marino S., Fuller M.T. (2004) Testis-specific TAF homologs collaborate to control a tissue-specific transcription program. Development. 2004 Nov;131(21):5297-308.

Hwa, J.J., Hiller, M.A., Fuller, M.T., and Santel, A. (2002). Differential expression of the Drosophila mitofusin genes fuzzy onions (fzo) and dmfn. Mechanisms of development 116, 213-216.

Schulz, C., Kiger, A.A., Tazuke, S.I., Yamashita, Y.M., Pantalena-Filho, L.C., Jones, D.L., Wood, C.G., and Fuller, M.T. (2004). A misexpression screen reveals effects of bag-of-marbles and TGF beta class signaling on the Drosophila male germ-line stem cell lineage. Genetics 167, 707-723.

Perezgasga, L., Jiang, J., Bolival, B., Jr., Hiller, M., Benson, E., Fuller, M.T., and White-Cooper, H. (2004). Regulation of transcription of meiotic cell cycle and terminal differentiation genes by the testis-specific Zn-finger protein matotopetli. Development (Cambridge, England) 131, 1691-1702.

Yamashita, Y.M., Jones, D.L., and Fuller, M.T. (2003). Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome. Science (New York, NY 301, 1547-1550.

Santel, A., Frank, S., Gaume, B., Herrler, M., Youle, R.J., and Fuller, M.T. (2003). Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells. Journal of cell science 116, 2763-2774.

Farkas, R., M.G. Giansanti, M. Gatti, M.T. Fuller. (2003). The Drosophila Cog5 homolog is required for cytokinesis, polarized cell growth, and assembly of specialized Golgi architecture during spermatogenesis. Molecular Biology of the Cell. in press.

Schulz, C., C. Wood, D.L. Jones, S. Tazuke, and M.T. Fuller. (2002). Signaling from germ cells mediated by the rhomboid homologue stet organizes encapsulation by somatic support cells. Development 129: 4523-4534.

Hwa, J.J., M.A. Hiller, M.T. Fuller and A. Santel (2002) Differential expression of the Drosophila mitofusin genes fuzzy onions (fzo) and dmfn. Mechanisms of Development
116: 213-216.

Tazuke, S. C. Schulz, L. Gilboa, M. Fogarty, A. Mahowald, R. Lehmann, and M.T. Fuller (2001). A germline-specific gap junction protein required for survival of differentiating early germ cells. Development 129: 2529-2539.

Schulz, C., L. Perezgasga, M.T. Fuller (2001) Genetic analysis of dPsa, the Drosophila orthologue of puromycin-sensitive aminopeptidase, suggest redunancy of aminopeptidases.
Dev. Genes Evol. 211: 581-588.

Kiger, A.A., D. L. Jones, C. Schulz, M. Rogers, and M. T. Fuller. (2001) Stem Cell Self-Renewal specified by JAK-STAT Activation in Response to a Support Cell Cue 294:

Hiller, M., T.-Y. Lin, C. Wood, and M. T. Fuller: (2001)Developmental regulation of transcription by a tissue-specific TAF homolog. Genes & Development 15: 1021-1030.

Kiger, A. and M.T. Fuller (2001) Male Germ Line Stem Cells. In Stem Cells, (D. Gottlieb, R. Gardner, and D. Marshak, eds.) Cold Spring Harbor Press, cold Spring Harbor, New York. pp.

Santel, A. and M.T. Fuller. (2001). Control of mitochondrial morphology by a human Mitofusin protein. J. Cell Sci 114: 867-874.

White-Cooper, H., D. Leroy, A. MacQueen and M.T. Fuller: (2000) Transcription of meiotic cell cycle and terminal differentiation genes depends on a conserved chromatin associated protein,
whose nuclear localisation is regulated. Development 127: 5463-5473.

Kiger, A., H.White-Cooper, and M.T. Fuller: (2000) Somatic support cells restrict germ line stem cell self-renewal and promote differentiation. Nature 407: 750-754