GO-defined Gene Sets
GO ID
GO Description
49
tRNA binding
59
protein-nucleus import, docking
74
regulation of cell cycle
75
cell cycle checkpoint
79
regulation of cyclin dependent protein kinase activity
82
G1/S transition of mitotic cell cycle
118
histone deacetylase complex
119
mediator complex
122
negative regulation of transcription from Pol II promoter
139
Golgi membrane
146
microfilament motor activity
151
ubiquitin ligase complex
159
protein phosphatase type 2A complex
165
MAPKKK cascade
166
nucleotide binding
175
3'-5'-exoribonuclease activity
187
activation of MAPK
188
inactivation of MAPK
228
nuclear chromosome
245
spliceosome assembly
287
magnesium ion binding
398
nuclear mRNA splicing, via spliceosome
502
proteasome complex (sensu Eukarya)
775
chromosome, pericentric region
776
kinetochore
785
chromatin
786
nucleosome
902
cellular morphogenesis
910
cytokinesis
1501
skeletal development
1503
ossification
1525
angiogenesis
1539
ciliary/flagellar motility
1558
regulation of cell growth
3682
chromatin binding
3684
damaged DNA binding
3690
double-stranded DNA binding
3697
single-stranded DNA binding
3702
RNA polymerase II transcription factor activity
3704
specific RNA polymerase II transcription factor activity
3707
steroid hormone receptor activity
3712
transcription cofactor activity
3713
transcription coactivator activity
3714
transcription corepressor activity
3725
double-stranded RNA binding
3729
mRNA binding
3735
structural constituent of ribosome
3743
translation initiation factor activity
3746
translation elongation factor activity
3754
chaperone activity
3755
peptidyl-prolyl cis-trans isomerase activity
3773
heat shock protein activity
3774
motor activity
3777
microtubule motor activity
3779
actin binding
3823
antigen binding
3899
DNA-directed RNA polymerase activity
3924
GTPase activity
3925
small monomeric GTPase activity
3927
heterotrimeric G-protein GTPase activity
3954
NADH dehydrogenase activity
3995
acyl-CoA dehydrogenase activity
4003
ATP-dependent DNA helicase activity
4004
ATP-dependent RNA helicase activity
4009
ATP-binding cassette (ABC) transporter activity
4024
alcohol dehydrogenase activity, zinc-dependent
4089
carbonate dehydratase activity
4114
3',5'-cyclic-nucleotide phosphodiesterase activity
4129
cytochrome-c oxidase activity
4143
diacylglycerol kinase activity
4175
endopeptidase activity
4177
aminopeptidase activity
4179
membrane alanyl aminopeptidase activity
4180
carboxypeptidase activity
4182
carboxypeptidase A activity
4197
cysteine-type endopeptidase activity
4198
calpain activity
4221
ubiquitin thiolesterase activity
4222
metalloendopeptidase activity
4252
serine-type endopeptidase activity
4263
chymotrypsin activity
4289
subtilase activity
4293
tissue kallikrein activity
4295
trypsin activity
4364
glutathione transferase activity
4383
guanylate cyclase activity
4385
guanylate kinase activity
4386
helicase activity
4407
histone deacetylase activity
4428
inositol/phosphatidylinositol kinase activity
4435
phosphoinositide phospholipase C activity
4437
inositol/phosphatidylinositol phosphatase activity
4497
monooxygenase activity
4519
endonuclease activity
4522
pancreatic ribonuclease activity
4527
exonuclease activity
4550
nucleoside-diphosphate kinase activity
4553
hydrolase activity, hydrolyzing O-glycosyl compounds
4601
peroxidase activity
4623
phospholipase A2 activity
4629
phospholipase C activity
4653
polypeptide N-acetylgalactosaminyltransferase activity
4675
transmembrane receptor protein serine/threonine kinase activity
4685
calcium/calmodulin-dependent protein kinase activity
4693
cyclin-dependent protein kinase activity
4707
MAP kinase activity
4713
protein-tyrosine kinase activity
4714
transmembrane receptor protein tyrosine kinase activity
4715
non-membrane spanning protein tyrosine kinase activity
4721
phosphoprotein phosphatase activity
4722
protein serine/threonine phosphatase activity
4725
protein tyrosine phosphatase activity
4730
pseudouridylate synthase activity
4759
serine esterase activity
4835
tubulin-tyrosine ligase activity
4840
ubiquitin conjugating enzyme activity
4842
ubiquitin-protein ligase activity
4843
ubiquitin-specific protease activity
4857
enzyme inhibitor activity
4864
protein phosphatase inhibitor activity
4866
endopeptidase inhibitor activity
4867
serine-type endopeptidase inhibitor activity
4869
cysteine protease inhibitor activity
4888
transmembrane receptor activity
4889
nicotinic acetylcholine-activated cation-selective channel activity
4890
GABA-A receptor activity
4895
cell adhesion receptor activity
4896
hematopoietin/interferon-class (D200-domain) cytokine receptor activity
4930
G-protein coupled receptor activity
4970
inotropic glutamate receptor activity
4984
olfactory receptor activity
4993
serotonin receptor activity
5001
transmembrane receptor protein tyrosine phosphatase activity
5003
ephrin receptor activity
5044
scavenger receptor activity
5057
receptor signaling protein activity
5070
SH3/SH2 adaptor protein activity
5083
small GTPase regulatory/interacting protein activity
5085
guanyl-nucleotide exchange factor activity
5089
Rho guanyl-nucleotide exchange factor activity
5096
GTPase activator activity
5100
Rho GTPase activator activity
5102
receptor binding
5125
cytokine activity
5126
hematopoietin/interferon-class (D200-domain) cytokine receptor binding
5149
interleukin-1 receptor binding
5158
insulin receptor binding
5164
tumor necrosis factor receptor binding
5178
integrin binding
5179
hormone activity
5184
neuropeptide hormone activity
5200
structural constituent of cytoskeleton
5201
extracellular matrix structural constituent
5212
structural constituent of eye lens
5216
ion channel activity
5230
extracellular ligand-gated ion channel activity
5234
glutamate-gated ion channel activity
5242
inward rectifier potassium channel activity
5244
voltage-gated ion channel activity
5245
voltage-gated calcium channel activity
5247
voltage-gated chloride channel activity
5248
voltage-gated sodium channel activity
5249
voltage-gated potassium channel activity
5251
delayed rectifier potassium channel activity
5261
cation channel activity
5262
calcium channel activity
5267
potassium channel activity
5279
amino acid-polyamine transporter activity
5319
lipid transporter activity
5328
neurotransmitter:sodium symporter activity
5351
sugar porter activity
5386
carrier activity
5391
sodium/potassium-exchanging ATPase activity
5452
inorganic anion exchanger activity
5478
intracellular transporter activity
5488
binding
5489
electron transporter activity
5496
steroid binding
5506
iron ion binding
5507
copper ion binding
5516
calmodulin binding
5518
collagen binding
5520
insulin-like growth factor binding
5529
sugar binding
5540
hyaluronic acid binding
5543
phospholipid binding
5544
calcium-dependent phospholipid binding
5578
extracellular matrix
5581
collagen
5604
basement membrane
5625
soluble fraction
5635
nuclear membrane
5643
nuclear pore
5653
perinuclear space
5654
nucleoplasm
5665
DNA-directed RNA polymerase II, core complex
5667
transcription factor complex
5669
transcription factor TFIID complex
5681
spliceosome complex
5694
chromosome
5730
nucleolus
5732
small nucleolar ribonucleoprotein complex
5741
mitochondrial outer membrane
5743
mitochondrial inner membrane
5744
mitochondrial inner membrane presequence translocase complex
5746
mitochondrial electron transport chain
5759
mitochondrial matrix
5763
mitochondrial small ribosomal subunit
5764
lysosome
5768
endosome
5769
early endosome
5777
peroxisome
5779
integral to peroxisomal membrane
5788
endoplasmic reticulum lumen
5789
endoplasmic reticulum membrane
5792
microsome
5795
Golgi stack
5802
Golgi trans face
5813
centrosome
5819
spindle
5829
cytosol
5834
heterotrimeric G-protein complex
5839
proteasome core complex (sensu Eukarya)
5840
ribosome
5842
cytosolic large ribosomal subunit (sensu Eukarya)
5843
cytosolic small ribosomal subunit (sensu Eukarya)
5856
cytoskeleton
5858
axonemal dynein complex
5859
muscle myosin
5863
striated muscle thick filament
5871
kinesin complex
5874
microtubule
5875
microtubule associated complex
5882
intermediate filament
5884
actin filament
5891
voltage-gated calcium channel complex
5892
nicotinic acetylcholine-gated receptor-channel complex
5905
coated pit
5911
intercellular junction
5922
connexon complex
5923
tight junction
5942
phosphoinositide 3-kinase complex
5975
carbohydrate metabolism
6006
glucose metabolism
6091
energy pathways
6094
gluconeogenesis
6096
glycolysis
6099
tricarboxylic acid cycle
6120
mitochondrial electron transport, NADH to ubiquinone
6139
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
6171
cAMP biosynthesis
6259
DNA metabolism
6260
DNA replication
6270
DNA replication initiation
6281
DNA repair
6289
nucleotide-excision repair
6298
mismatch repair
6306
DNA methylation
6310
DNA recombination
6323
DNA packaging
6325
establishment and/or maintenance of chromatin architecture
6333
chromatin assembly/disassembly
6334
nucleosome assembly
6338
chromatin remodeling
6350
transcription
6352
transcription initiation
6357
regulation of transcription from Pol II promoter
6364
rRNA processing
6366
transcription from Pol II promoter
6367
transcription initiation from Pol II promoter
6383
transcription from Pol III promoter
6396
RNA processing
6397
mRNA processing
6401
RNA catabolism
6406
mRNA-nucleus export
6413
translational initiation
6414
translational elongation
6417
regulation of protein biosynthesis
6445
regulation of translation
6446
regulation of translational initiation
6457
protein folding
6461
protein complex assembly
6464
protein modification
6469
negative regulation of protein kinase activity
6470
protein amino acid dephosphorylation
6471
protein amino acid ADP-ribosylation
6486
protein amino acid glycosylation
6487
N-linked glycosylation
6493
O-linked glycosylation
6511
ubiquitin-dependent protein catabolism
6512
ubiquitin cycle
6520
amino acid metabolism
6605
protein targeting
6606
protein-nucleus import
6607
NLS-bearing substrate-nucleus import
6626
protein-mitochondrial targeting
6629
lipid metabolism
6631
fatty acid metabolism
6633
fatty acid biosynthesis
6635
fatty acid beta-oxidation
6644
phospholipid metabolism
6694
steroid biosynthesis
6695
cholesterol biosynthesis
6725
aromatic compound metabolism
6730
one-carbon compound metabolism
6783
heme biosynthesis
6796
phosphate metabolism
6801
superoxide metabolism
6805
xenobiotic metabolism
6807
nitrogen metabolism
6811
ion transport
6812
cation transport
6813
potassium ion transport
6814
sodium ion transport
6816
calcium ion transport
6820
anion transport
6821
chloride transport
6826
iron ion transport
6836
neurotransmitter transport
6839
mitochondrial transport
6865
amino acid transport
6869
lipid transport
6874
calcium ion homeostasis
6879
iron ion homeostasis
6887
exocytosis
6888
ER to Golgi transport
6891
intra-Golgi transport
6897
endocytosis
6898
receptor mediated endocytosis
6904
vesicle docking during the process of exocytosis
6916
anti-apoptosis
6917
induction of apoptosis
6919
caspase activation
6928
cell motility
6935
chemotaxis
6936
muscle contraction
6939
smooth muscle contraction
6941
striated muscle contraction
6944
membrane fusion
6950
response to stress
6952
defense response
6953
acute-phase response
6954
inflammatory response
6957
complement activation, alternative pathway
6958
complement activation, classical pathway
6959
humoral immune response
6968
cellular defense response
6979
response to oxidative stress
7004
telomerase-dependent telomere maintenance
7010
cytoskeleton organization and biogenesis
7018
microtubule-based movement
7031
peroxisome organization and biogenesis
7049
cell cycle
7050
cell cycle arrest
7059
chromosome segregation
7067
mitosis
7088
regulation of mitosis
7126
meiosis
7131
meiotic recombination
7154
cell communication
7156
homophilic cell adhesion
7157
heterophilic cell adhesion
7160
cell-matrix adhesion
7162
negative regulation of cell adhesion
7166
cell surface receptor linked signal transduction
7169
transmembrane receptor protein tyrosine kinase signaling pathway
7173
epidermal growth factor receptor signaling pathway
7179
transforming growth factor beta receptor signaling pathway
7187
G-protein signaling, coupled to cyclic nucleotide second messenger
7188
G-protein signaling, coupled to cAMP nucleotide second messenger
7190
adenylate cyclase activation
7194
negative regulation of adenylate cyclase activity
7200
G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
7202
phospholipase C activation
7204
cytosolic calcium ion concentration elevation
7205
protein kinase C activation
7214
gamma-aminobutyric acid signaling pathway
7218
neuropeptide signaling pathway
7222
frizzled signaling pathway
7223
frizzled-2 signaling pathway
7229
integrin-mediated signaling pathway
7243
protein kinase cascade
7249
I-kappaB kinase/NF-kappaB cascade
7254
JNK cascade
7259
JAK-STAT cascade
7264
small GTPase mediated signal transduction
7265
RAS protein signal transduction
7266
Rho protein signal transduction
7269
neurotransmitter secretion
7283
spermatogenesis
7292
female gamete generation
7338
fertilization (sensu Animalia)
7409
axonogenesis
7411
axon guidance
7416
synaptogenesis
7417
central nervous system development
7420
brain development
7422
peripheral nervous system development
7498
mesoderm development
7507
heart development
7517
muscle development
7530
sex determination
7548
sex differentiation
7565
pregnancy
7582
physiological process
7584
response to nutrients
7585
respiratory gaseous exchange
7586
digestion
7588
excretion
7596
blood coagulation
7600
sensory perception
7601
visual perception
7602
phototransduction
7605
perception of sound
7608
perception of smell
7610
behavior
7611
learning and/or memory
7623
circadian rhythm
7631
feeding behavior
8009
chemokine activity
8015
circulation
8016
regulation of heart rate
8017
microtubule binding
8020
G-protein coupled photoreceptor activity
8021
synaptic vesicle
8022
protein C-terminus binding
8026
ATP-dependent helicase activity
8033
tRNA processing
8037
cell recognition
8047
enzyme activator activity
8067
metabotropic glutamate, GABA-B-like receptor activity
8076
voltage-gated potassium channel complex
8080
N-acetyltransferase activity
8083
growth factor activity
8092
cytoskeletal protein binding
8094
DNA-dependent ATPase activity
8134
transcription factor binding
8137
NADH dehydrogenase (ubiquinone) activity
8138
protein tyrosine/serine/threonine phosphatase activity
8146
sulfotransferase activity
8168
methyltransferase activity
8201
heparin binding
8202
steroid metabolism
8203
cholesterol metabolism
8217
regulation of blood pressure
8219
cell death
8233
peptidase activity
8234
cysteine-type peptidase activity
8235
metalloexopeptidase activity
8237
metallopeptidase activity
8248
pre-mRNA splicing factor activity
8271
sulfate porter activity
8272
sulfate transport
8277
regulation of G-protein coupled receptor protein signaling pathway
8284
positive regulation of cell proliferation
8285
negative regulation of cell proliferation
8287
protein serine/threonine phosphatase complex
8289
lipid binding
8305
integrin complex
8307
structural constituent of muscle
8320
protein carrier activity
8324
cation transporter activity
8373
sialyltransferase activity
8378
galactosyltransferase activity
8380
RNA splicing
8408
3'-5' exonuclease activity
8415
acyltransferase activity
8420
CTD phosphatase activity
8483
transaminase activity
8484
sulfuric ester hydrolase activity
8527
taste receptor activity
8543
fibroblast growth factor receptor signaling pathway
8544
epidermis development
8601
protein phosphatase type 2A regulator activity
8603
cAMP-dependent protein kinase regulator activity
8624
induction of apoptosis by extracellular signals
8643
carbohydrate transport
8654
phospholipid biosynthesis
8656
caspase activator activity
8757
S-adenosylmethionine-dependent methyltransferase activity
9055
electron carrier activity
9058
biosynthesis
9116
nucleoside metabolism
9117
nucleotide metabolism
9306
protein secretion
9611
response to wounding
9613
response to pest/pathogen/parasite
9615
response to virus
9618
response to pathogenic bacteria
9636
response to toxin
9653
morphogenesis
9790
embryonic development
9887
organogenesis
9966
regulation of signal transduction
9986
cell surface
10033
response to organic substance
15026
coreceptor activity
15031
protein transport
15036
disulfide oxidoreductase activity
15075
ion transporter activity
15285
connexon channel activity
15288
porin activity
15293
symporter activity
15297
antiporter activity
15450
protein translocase activity
15459
potassium channel regulator activity
15464
acetylcholine receptor activity
15629
actin cytoskeleton
15662
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
15671
oxygen transport
15711
organic anion transport
15986
ATP synthesis coupled proton transport
15992
proton transport
16042
lipid catabolism
16049
cell growth
16055
Wnt receptor signaling pathway
16192
vesicle-mediated transport
16197
endosome transport
16251
general RNA polymerase II transcription factor activity
16301
kinase activity
16303
phosphatidylinositol 3-kinase activity
16310
phosphorylation
16329
apoptosis regulator activity
16337
cell-cell adhesion
16339
calcium-dependent cell-cell adhesion
16455
RNA polymerase II transcription mediator activity
16459
myosin
16469
proton-transporting two-sector ATPase complex
16481
negative regulation of transcription
16493
C-C chemokine receptor activity
16526
G-protein coupled receptor activity, unknown ligand
16563
transcriptional activator activity
16564
transcriptional repressor activity
16567
protein ubiquitination
16568
chromatin modification
16575
histone deacetylation
16702
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
16712
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
16757
transferase activity, transferring glycosyl groups
16779
nucleotidyltransferase activity
16788
hydrolase activity, acting on ester bonds
16798
hydrolase activity, acting on glycosyl bonds
16805
dipeptidase activity
16820
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
16829
lyase activity
16853
isomerase activity
16874
ligase activity
16887
ATPase activity
16998
cell wall catabolism
17017
MAP kinase phosphatase activity
17148
negative regulation of protein biosynthesis
18685
alkane 1-monooxygenase activity
19079
viral genome replication
19538
protein metabolism
19717
synaptosome
19722
calcium-mediated signaling
19735
antimicrobial humoral response (sensu Vertebrata)
19825
oxygen binding
19866
inner membrane
19867
outer membrane
19884
antigen presentation, exogenous antigen
19885
antigen processing, endogenous antigen via MHC class I
19886
antigen processing, exogenous antigen via MHC class II
19898
extrinsic to membrane
19899
enzyme binding
19901
protein kinase binding
19992
diacylglycerol binding
30001
metal ion transport
30019
tryptase activity
30036
actin cytoskeleton organization and biogenesis
30048
actin filament-based movement
30097
hemopoiesis
30101
natural killer cell activation
30106
MHC class I receptor activity
30125
clathrin vesicle coat
30145
manganese ion binding
30154
cell differentiation
30159
receptor signaling complex scaffold activity
30168
platelet activation
30173
integral to Golgi membrane
30176
integral to endoplasmic reticulum membrane
30183
B-cell differentiation
30286
dynein complex
30308
negative regulation of cell growth
30317
sperm motility
30374
ligand-dependent nuclear receptor transcription coactivator activity
30521
androgen receptor signaling pathway
30528
transcription regulator activity
30529
ribonucleoprotein complex
30530
heterogeneous nuclear ribonucleoprotein complex
30532
small nuclear ribonucleoprotein complex
30574
collagen catabolism
30594
neurotransmitter receptor activity
30693
caspase activity
40007
growth
42110
T-cell activation
42127
regulation of cell proliferation
42355
L-fucose catabolism
42493
response to drug
42623
ATPase activity, coupled
42742
defense response to bacteria
42803
protein homodimerization activity
42809
vitamin D receptor binding
42981
regulation of apoptosis
43123
positive regulation of I-kappaB kinase/NF-kappaB cascade
45012
MHC class II receptor activity
45028
purinergic nucleotide receptor activity, G-protein coupled
45087
innate immune response
45202
synapse
45449
regulation of transcription
45786
negative regulation of cell cycle
45892
negative regulation of transcription, DNA-dependent
45893
positive regulation of transcription, DNA-dependent
45941
positive regulation of transcription
46872
metal ion binding
46873
metal ion transporter activity
46933
hydrogen-transporting ATP synthase activity, rotational mechanism
46961
hydrogen-transporting ATPase activity, rotational mechanism
46966
thyroid hormone receptor binding
46982
protein heterodimerization activity
47115
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
50909
perception of taste

Curated Gene Sets
ID
Description
JZ1
cytosolic ribosome
JZ2
electron transport chain