Global Analysis of Gene Expression in the Dauer Larvae of Caenorhabditis elegans

John Wang ¹ and Stuart K. Kim^1,2,3

¹Department of Developmental Biology
Stanford University Medical Center
Stanford, CA 94305

²Department of Genetics
Stanford University Medical Center
Stanford, CA 94305

³corresponding author
650-725-7671
650-725-7739
kim@cmgm.stanford.edu

Figure 3. A profile of gene expression during the dauer exit and L1 starvation time courses.

A self-organizing map was used to cluster the 1984 dauer-specific genes with common normalized expression patterns into 45 nodes using 1.5x107 iterations. Each row represents the average expression pattern of the genes in the node (14-100 genes, average of 45). The columns represent different times during the time course except for the first column (D/L1) which is the ratio of dauer to L1 at 0 hours. The nodes have also been aggregated into five groups based on the dauer exit time course expression patterns as labeled. These metagroups are partitioned into many nodes because the expression patterns in the L1 starvation time course and relative dauer-enrichment are different. Because normalized data are shown, there are no units on the scale bar. (D) is dauer and (L1) is L1 larvae. Full data set are shown in Supplemental Fig. [3].

Home   PDF of paper   Figures and Tables in paper   Examine Expression Profile
  Supplemental Figures and Tables   Access SMD   Top   Contact