Global Analysis of Gene Expression in the Dauer Larvae of Caenorhabditis elegans
John Wang 1 and Stuart K. Kim1,2,3
1Department of Developmental Biology
Stanford University Medical Center
Stanford, CA 94305
2Department of Genetics
Stanford University Medical Center
Stanford, CA 94305
3corresponding author
650-725-7671
650-725-7739
kim@cmgm.stanford.edu
Figure 5. Dauer expression of glyoxylate pathway genes.
The glyoxylate pathway genes are up-regulated in dauers as inferred from changes in gene expression. Except C05E4.9, which encodes both isocitrate lyase and malate synthase activity, the rest of the C. elegans genes encoding the enzymes that catalyze each step in glyoxylate pathway have not been explicitly define although the ORFs illustrated show significant homology to the respective enzymes. Red lettering and boxes refer to genes that are dauer-enriched (p<0.01) when comparing dauer at 0 hours to dauer at 12 hours. Correspondingly, red arrows indicate inferred high levels of enzyme activity in dauers. Green lettering and boxes refer to genes and enzymatic steps that are down regulated (p<0.01) when comparing dauer at 0 hours to dauer at 12 hours. Black lettering in gray boxes indicates no significant difference in expression. The magnitude of induction or repression for each gene is indicated. Some key metabolic intermediates are shown.Home
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