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Stuart Kim Lab

Stanford University

Dept. Dev. Biology and Genetics

 

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Our long term goal is to understand the process of growing old, and then try to slow down or reverse the aging process. We want to understand the underlying clock for aging that dictates the rate at which normal aging occurs. Aging is a strong risk factor for many diseases, such as cancer and cardiovascular disease.  If we could understand the underlying basis for aging, we could reduce the risk of getting these diseases. 

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C. elegans aging

We are using the nematode C. elegans as a model system for aging, because it has a rapid lifespan, a small size, a powerful genetic toolkit and many mutants are already known to lengthen lifespan. Our approach is to first identify genes that are differentially expressed in old versus young animals, and then to dissect apart how changes in these genes lead to functional decline and senescence in old age.

 

 

Human aging

We are studying aging of the human kidney, which begins to show functional decline around age 40. Kidneys age at different rates, such that some people show little or no effects of aging whereas others show rapid functional decline of the kidney.

Supercentenarians (110 years or older) are the world’s oldest people. We performed whole-genome sequencing on 17 supercentenarians to explore the genetic basis underlying extreme human longevity.

 

 

 

 

 

The Kim Lab is located at Stanford University in the Department of Developmental Biology. Maps to the lab can be found here.

 

 

 

 

Mailing address:

Stanford University Medical Center

Department of Developmental Biology

279 Campus Drive

Stanford, CA 94305-5329

phone: ++1-650-725-7671

fax: ++1-650-725-7739

   

Last modified 8/2012