Table 1. Network components.

Component	Size^a	Biological Function^b	Genes in component^c	Enrichment; P-value^d
1	353	cellular cortex	16/57	2.7; 1e-6.1
		Signaling	44/321	1.3; 1e-5.8
		animal-specific	195/1441	1.3; 1e-7.2
2	349	ribosome biogenesis	102/125	8.0; 1e-83
3	320	energy generation	77/147	5.6; 1e-42
4	271	Proteasome	31/32	12; 1e-32
5	241	cell cycle	110/202	7.7; 1e-85
6	201	general transcription	47/142	5.6; 1e-24
7	167	animal-specific	124/1441	1.8; 1e-17
8	156	translation initiation, elongation, and termination	20/110	4.0; 1e-7.3
		aminoacyl tRNA biosynthesis	14/31	9.9; 1e-11
9	139	ribosomal protein subunits	74/78	23; 1e-107
10	92	Secretion	37/85	16; 1e-38
11	65	Neuronal	17/42	21; 1e-19
		animal-specific	58/1441	2.1; 1e-15
12	57	lipid metabolism	6/16	22; 1e-7
		peroxisome	14/32	26; 1e-17

^aThe total number of meta-genes.

^bBiological functions were based on edited terms from Gene Ontology.

^cThe number of meta-genes in both the biological function group and in the component divided by the total number of meta-genes in the biological function group that were also in the network.

^dFold enrichment over the number expected by chance and P-value. The P-value was computed as the probability of obtaining the observed number of overlaps by chance under a hypergeometric distribution.