Table 1. Network components.

Component

Sizea

Biological Functionb

Genes in componentc

Enrichment;

P-valued

1

353

cellular cortex

16/57

2.7; 1e-6.1

 

 

Signaling

44/321

1.3; 1e-5.8

 

 

animal-specific

195/1441

1.3; 1e-7.2

2

349

ribosome biogenesis

102/125

8.0; 1e-83

3

320

energy generation

77/147

5.6; 1e-42

4

271

Proteasome

31/32

12; 1e-32

5

241

cell cycle

110/202

7.7; 1e-85

6

201

general transcription

47/142

5.6; 1e-24

7

167

animal-specific

124/1441

1.8; 1e-17

8

156

translation initiation, elongation, and termination

20/110

4.0; 1e-7.3

 

 

aminoacyl tRNA biosynthesis

14/31

9.9; 1e-11

9

139

ribosomal protein subunits

74/78

23; 1e-107

10

92

Secretion

37/85

16; 1e-38

11

65

Neuronal

17/42

21; 1e-19

 

 

animal-specific

58/1441

2.1; 1e-15

12

57

lipid metabolism

6/16

22; 1e-7

 

 

peroxisome

14/32

26; 1e-17

 

aThe total number of meta-genes.

bBiological functions were based on edited terms from Gene Ontology.

cThe number of meta-genes in both the biological function group and in the component divided by the total number of meta-genes in the biological function group that were also in the network.

dFold enrichment over the number expected by chance and P-value.  The P-value was computed as the probability of obtaining the observed number of overlaps by chance under a hypergeometric distribution.