| S-Table 3. Most Genes whose expression patterns were previously characterized in detail, | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| and were identified as enriched in L1 muscle by mRNA tagging, are at least expressed in muscle. | ||||||||||||
| Agreement with | Expression | |||||||||||
| Number | Name | Gene (a) | Previous Data (b) | Pattern (c) | Reference | |||||||
| 1 | act-1 | T04C12.4 | + | UN | Krause et al. J Mol Biol 208, 381-92 (1989). | |||||||
| 2 | atx-2 | D2045.1 | + | SM, N, I | Kiehl et al. J Mol Neurosci 15, 231-41. (2000). | |||||||
| 3 | C40H1.6 | C40H1.6 | + | BWM, H | I. Hope, personal communication. | |||||||
| 4 | cct-1 | T05C12.7 | + | SM, N | Leroux et al. Biochem Biophys Res Commun 241, 687-92 (1997). | |||||||
| 5 | clk-1 | ZC395.2 | + | NU | Miyadera et al. J Biol Chem 276, 7713-7716. (2001). | |||||||
| 6 | cut-1 | C47G2.1 | - | D | Lassandro et al. Dev Biol 146, 519-30 (1991). | |||||||
| 7 | daf-16b | na | + | NU | Paradis et al. Nature 389, 994-9 (1997). | |||||||
| 8 | daf-2 | Y55D5A_391.B | + | M, N | Crowder et al. 2001 International Worm Meeting abstract 246 | |||||||
| 9 | eft-3 | F31E3.5 | + | NU | Mitrovich et al. Genes And Development 14, 2173-84 (2000). | |||||||
| 10 | F55A8.2 | F55A8.2 | + | SM, N, P, SPT | Stansberry et al. J Neurochem 76, 1177-1187. (2001). | |||||||
| 11 | gpd-2 | K10B3.8 | + | BWM | Yarbrough et al. J Biol Chem 259, 14711-20 (1984). | |||||||
| 12 | gpd-3 | K10B3.7 | + | BWM | Lee et al. Gene 121: 227-235 1992 | |||||||
| 13 | ima-1 | F32E10.4 | + | NU | Geles & Adam. Dev Suppl 128, 1817-1830. (2001); personal communication. | |||||||
| 14 | lag-1 | K08B4.1 | + | NU | Hermann et al. Dev Suppl 127, 3429-3440 (2000). | |||||||
| 15 | lbp-2 | F40F4.2 | + | SM | Plenefisch et al. Mol Biochem Parasitol 105, 223-36 (2000). | |||||||
| 16 | lbp-3 | F40F4.4 | + | SM, H | Plenefisch et al. Mol Biochem Parasitol 105, 223-36 (2000). | |||||||
| 17 | let-2 | F01G12.5 | + | BWM, SG | Graham et al. J Cell Biol 137, 1171-83 (1997). | |||||||
| 18 | let-70 | M7.1 | + | BWM, N, P, H | Zhen et al. Embo Journal 15, 3229-37 (1996). | |||||||
| 19 | let-858 | F33A8.1 | + | NU | Kelly et al. Genetics 146, 227-38 (1997). | |||||||
| 20 | lin-28 | F02E9.2A | + | SM, N, I | Moss et al. Cell 88, 637-46 (1997). | |||||||
| 21 | mca-4 | K11D9.2 | + | SM, H, EC | Cho et al. Gene 261, 211-219. (2000). | |||||||
| 22 | mec-7 | ZK154.3 | - | N | Hamelin et al. Embo Journal 11, 2885-93 (1992). | |||||||
| 23 | nhr-78 | F36A4.14 | + | NU | Miyabayashi et al. Dev Biol 215, 314-31 (1999). | |||||||
| 24 | pdi-2 | C07A12.4 | + | H, SM | Winter et al. Mol Cell Biol 20, 4084-4093 (2000). | |||||||
| 25 | rgs-1 | C05B5.7 | - | N | Dong et al. Genes And Development 14, 2003-2014 (2000). | |||||||
| 26 | rsp-5 | T28D9.2 | + | NU | Kawano et al. Mech Dev 95, 67-76 (2000). | |||||||
| 27 | srq-1 | F59B2.13 | + | IM, N, EC, N | Lynch et al. Nat Genet 11, 309-13 (1995). | |||||||
| 28 | syd-2 | F59F5.6 | + | SM, N, P | Serra-Pages et al. J Biol Chem 273, 15611-20 (1998). | |||||||
| 29 | unc-14 | K10D3.2 | + | N, ADM | Ogura et al. Genes And Development 11, 1801-11 (1997). | |||||||
| 30 | unc-23 | H14N18.1 | + | SM, P, H | Rahmani & Moerman. 2001 International Worm Meeting abstract 263 | |||||||
| 31 | unc-36 | C50C3.9 | + | BWM | R. Kerr & B. Schafer, personal communication. | |||||||
| (a) Each gene is present in the list of 1364 L1 muscle genes (p<0.001). Together with the 16 positive controls (see S-Table 2), | ||||||||||||
| there are a total of 47 genes in the list of 1364 "muscle-expressed" genes for which there is evidence in the literature of there being expressed in muscle. | ||||||||||||
| (b) The list of 1364 L1 muscle genes was searched for genes with expression patterns previously described in sufficient detail | ||||||||||||
| to ascertain muscle expression. Previous data either support (+) our findings that the gene is expressed in muscle, or do not (-). | ||||||||||||
| (c) The key to the expression patterns is: SM= striated muscle, N= Neurons, P= Pharynx, I= Intestine, SPT= Spermatheca, UN=Unknown, | ||||||||||||
| H= Hypodermis, IM= intestinal muscles, SG= Somatic Gonad, AM= All Muscles, DTC= Distal Tip Cells, EC= Excretory Cells, | ||||||||||||
| NU= Nearly Ubiquitous, ADM= Anal Depressor Muscle, D=Dauer, BWMS=body wall muscle. | ||||||||||||