Table 1.  Genes expressed in the same tissue tend to cluster along the chromosomes.

 

Total

Genes

Observed

Expected

 

Gene Groupa

Genesb

Consideredc

Clusteredd

Clusterede

P Valuef

L1 Muscle-Enriched Genes

1364

1304

386

310.1

7.2X10-5

Sperm-Enriched Genes

650

616

198

112

<10-15

Oocyte-Enriched Genes

258

242

26

14.4

0.0174

Germline-Intrinsic Genes

508

475

136

67.9

<10-15

mountain 00

2703

2377

962

868.9

5.8X10-4

mountain 01

1818

1662

435

465.9

0.8936

mountain 02

1465

1100

360

270.6

<10-15

mountain 03

1363

1166

316

271.8

0.0017

mountain 04

1195

1113

466

268.2

<10-15

mountain 05

1012

944

248

160.7

<10-15

mountain 06

978

915

214

159.8

1.6X10-4

mountain 07

909

840

133

130.7

0.3243

mountain 08

810

761

225

119.8

<10-15

mountain 09

786

744

172

102.8

<10-15

mountain 10

635

555

97

64.8

0.0013

mountain 11

587

546

133

71.5

<10-15

mountain 12

462

435

86

35.9

<10-15

mountain 13

396

368

49

27.3

1.3X10-5

mountain 14

353

331

46

22.1

4.4X10-5

Oxidoreductases

323

317

21

16.7

0.2252

Transcription Factors

255

214

8

8.6

0.5558

Lipid, Fatty Acid, and Sterol Metabolism Genes

281

280

12

12.4

0.5329

aThe genes in each list are given in supplemental Table 1.

bThe total number of genes considered

c The number of genes considered, after removing operons, putative tandem duplicates, and genes with uncertain genomic positions.

dThe number of genes in the gene group that are within 10 kb of another gene from the same group.

eThe number of clusters expected due to random chance.  Shown are the average number of clustered genes from 10,000 repetitions of randomly selecting the same number of genes from the genome as the experimental gene group and counting how many genes are within 10 kb of another gene from the same randomly selected list.

fThe probability that the observed number of genes that cluster could be matched or exceeded by chance.