Sequential Use of Transcriptional Profiling, Expression Quantitative Trait Mapping and Gene Association Implicates MMP20 in Human Kidney Aging

Heather E. Wheeler1, E. Jeffrey Metter2,3, Toshiko Tanaka2,3, Devin Absher4, John Higgins5, Jacob M. Zahn6, Julie Wilhelmy6, Ronald W. Davis6, Andrew Singleton7, Richard M. Myers4, Luigi Ferrucci2,3, Stuart K. Kim1,8*

 

1Department of Genetics, Stanford University Medical Center, Stanford, California 94305, USA, 2Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21225, USA, 3Medstar Research Institute, Baltimore, Maryland 21225, USA, 4HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA, 5Department of Pathology, Stanford University Medical Center, Stanford, California 94305, USA, 6Stanford Genome Technology Center, Palo Alto, California 94304, USA, 7Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland 20892, USA, 8Department of Developmental Biology, Stanford University Medical Center, Stanford,California 94305, USA

* To whom correspondence should be addressed.  Email: kim@cmgm.stanford.edu

 

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