Oxidative Dercarboxylation of Pyruvate

Pyruvate + CoA + NAD+ ---> Acetyl CoA + CO2 + NADH

 

 

 

 

 

 

 

 

 

 

 

Pyruvate Decarboxylase (E1 Subunit) Cofactors

 

 

 

 

 

 

 

 

 

 

 

 

Decarboxylation (E1 Subunit)

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Transfer of Acetyl Unit to Lipoic Acid (E1 Subunit)

 

 

 

 

 

 

 

 

 

 

Transacetylation (E2 Subunit)

NAD+ and FAD

 

 

Dehydrogenation of Reduced Lipoamide (E3 Subunit)